在自发高血压的老鼠中,次慢性经神经刺激降低了门诊血压
K Romero1,2, M A Gonzalez-Gonzalez3,4, D Lloyd1,2
1Departments of Biomedical EngineeringUniversity of Houston Houston TX 77204 USA.
IEEE open journal of engineering in medicine and biology
|December 19, 2024
概括
在高血压的老鼠中,常见的腹腔神经刺激有效降低了缩血压. 这种神经调节为耐药高血压提供了潜在的替代治疗方法.
科学领域:
- 神经调节是一种神经调节.
- 心血管生理学心血管生理学
- 医疗器械 医疗器械
背景情况:
- 常神经 (cPNS) 的急性电刺激降低了自发高血压 (SHR) 的大鼠的系统血压 (SBP).
- 在高血压中cPNS对门诊SBP的亚慢性影响仍未得到研究.
研究的目的:
- 评估使用可植入的无线神经刺激器对高血压进行为期5周的cPNS治疗的疗效.
- 在WKY和SHR模型中评估cPNS对亚慢性门诊SBP的影响.
主要方法:
- 开发一种可植入的无线WNClip神经刺激器.
- 每天cPNS (2Hz,单相,值强度,8分钟) 持续五周.
- 门诊SBP和心率监测.
主要成果:
- 在SHR动物 (-21 mmHg) 中,在第5周观察到SBP显著降低.
- 门诊SBP显示,从第1周到第5周 (-9 mmHg) 的显着下降.
- 在cPNS治疗期间没有检测到心率的显著变化.
结论:
- 常见的腹腔神经刺激显著降低了SBP,与拉米普利尔或脏皮等药理疗法相比.
- 常见腹部神经的神经调节是一种有前途的替代疗法,用于抵抗性高血压.
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