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长期COVID中的认知和神经精神症状的结构性MRI相关性:试点研究

Shantanu H Joshi^1,2, Prabha Siddarth³, Helen Lavretsky³

¹Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Frontiers in psychiatry

|December 19, 2024

概括

长期COVID患者在特定的大脑区域显示皮质厚度和灰质体积增加,这挑战了以前的缩发现. 这些大脑变化与长期COVID幸存者的症状严重程度和认知得分相关.

科学领域:

神经科学是一个神经科学.
放射学放射学是一门学科.
传染性疾病传染性疾病

背景情况:

SARS-CoV-2 感染 (PASC) 或长期COVID的急性后续影响大约7%的患者,20%的患者出现神经精神疾病症状.
长期COVID的神经成像研究对大脑结构变化产生了相互矛盾的结果,其中一些显示缩,另一些显示扩大.

研究的目的:

研究长期COVID患者和健康对照者之间的结构性大脑差异,特别是皮质边缘和背侧前额前额区域的灰色物质厚度.
探索长期COVID患者观察到的大脑结构变化和临床措施之间的关联.

主要方法:

使用结构磁共振成像 (MRI) 来比较灰色物质的厚度和体积.
专注于特定感兴趣的区域进行分析,包括尾部前部,地峡,后侧环状回形和面向中前线回形.

主要成果:

患有长期COVID的患者表现出后带带皮层和面皮层中额头回旋的皮质厚度增加.
在长期COVID患者的背带状和峡谷带状区域观察到较高的灰质体积.
皮层厚度和灰质量与长期COVID队列中的临床痴呆症评分和焦虑评分相关.

结论:

这些发现支持长期COVID中皮质缩的存在.
长期COVID中的结构性大脑变化与临床严重程度和神经精神症状有关.

关键词:

大脑大脑大脑的大脑大脑带状状圈 (Cingulate Gyrus) 是一个带状状圈.皮层厚度皮层厚度灰色物质的体积,灰色物质的体积.长时间的COVID.结构性核磁共振成像 (MRI)

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