病毒纳米技术用于入瘤免疫疗法
Anthony O Omole1,2,3,4, Zhongchao Zhao1,2,3,4, Sabrina Chang-Liao1,2,3,4
1Aiiso Yufeng Li Family Department of Chemical and Nano Engineering, University of California, San Diego, La Jolla, CA, USA.
Nature reviews bioengineering
|December 19, 2024
概括
病毒可以被设计成癌症免疫治疗的强大工具. 本综述探讨了利用病毒和类似病毒的粒子直接向瘤输送治疗,刺激强大的抗癌免疫反应.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 生物技术是生物技术.
背景情况:
- 病毒提供独特的纳米载体特性,用于向药物输送.
- 它们固有的免疫调节能力可以增强癌症免疫疗法.
- 各种病毒类型,包括瘤,菌体和植物病毒,都显示出治疗潜力.
研究的目的:
- 审查用于内免疫治疗的病毒和类似病毒的颗粒的设计.
- 讨论引发抗瘤免疫和全身反应的工程策略.
- 突出病毒载体作为药物输送系统的应用.
主要方法:
- 对针对免疫治疗的病毒工程现有文献的综述.
- 对解性病毒疗法,菌体和植物病毒的分析.
- 讨论病毒样粒子作为治疗平台.
主要成果:
- 病毒可以被功能化为有针对性的交付和货物封装.
- 工程病毒可以诱导本地和全身抗瘤免疫力.
- 病毒平台显示出新型药物输送系统的前景.
结论:
- 病毒和类似病毒的颗粒在内免疫疗法中是一个有前途的前沿.
- 设计这些药物可以克服癌症治疗中的挑战.
- 进一步的翻译研究对于临床应用至关重要.
相关概念视频
01:27Tumor Immunotherapy
475
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
475
01:30Cancer Vaccines
338
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
338