儿科血液学/瘤学患者的血液感染:武汉的一项单中心研究
Ibrahim Ahmed Saleh Murshed1, Lizhen Zhao1, Wenzhi Zhang1
1Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Frontiers in cellular and infection microbiology
|December 19, 2024
概括
血流感染 (BSI) 在接受化疗或干细胞移植的儿科癌症患者中很常见. 警监测和量身定制的策略对于管理这些感染和改善患者结果至关重要.
科学领域:
- 儿科瘤学 儿科瘤学
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 血流感染 (BSI) 对接受化疗或血造干细胞移植 (HSCT) 的儿科瘤血液病患者构成重大风险.
- 这些感染导致这种脆弱人群的发病率增加,住院时间延长和死亡率增加.
研究的目的:
- 追溯分析儿科瘤血液病患者BSI的流行病学和特征.
- 识别常见的病原体及其抗微生物敏感性模式.
- 了解BSI在化疗和HSCT不同阶段的时间分布.
主要方法:
- 在145名患有血液性恶性瘤,固体瘤或非恶性血液性疾病的儿科患者中对202个BSI进行了回顾性分析.
- 数据收集包括患者人口统计,临床特征,病原体识别和抗菌素敏感性测试.
- 分析的重点是诱导,巩固和维持化疗阶段以及HSCT后的感染发生.
主要成果:
- 格拉姆阳性细菌是最常见的致病剂 (58.4%),其次是格拉姆阴性细菌 (41%).
- 诱导化疗阶段显示BSI的发病率最高 (46.5%),主要在中性衰竭患者中 (88.3%).
- 葡萄球菌表皮菌 (19.8%),人类葡萄球菌 (16.3%) 和大肠杆菌 (8.4%) 是最常见的病原体.
结论:
- 在儿科瘤血液学中,BSI是一个关键的挑战,特别是在密集治疗阶段.
- 定制的感染监测和管理策略对于减轻BSI影响至关重要.
- 了解病原体的流行率和易感性是优化抗微生物治疗和改善患者治疗结果的关键.
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