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在印度人口中评估种族中立的淋巴膜过率估计方程
Ashok Kumar Yadav1, Jaskiran Kaur1, Prabhjot Kaur2
1Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Kidney international reports
|December 19, 2024
概括
较新的功能估计方程,包括无种族模型,无法准确预测印度人口的膜过率 (GFR). 需要进一步的研究来开发印度人的特定GFR方程,以确保准确的诊断和护理.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物标志物 生物标志物
- 流行病学 流行病学
背景情况:
- 淋巴膜过率 (GFR) 估计方程需要在不同种群中进行验证.
- 现有的基于肌的方程,如CKD-EPICr2009可能会高估印度人的GFR.
- 已经提出了使用肌素和囊素C的较新的无种族方程.
研究的目的:
- 评估印度人口中最近开发的无种族估计GFR (eGFR) 方程的性能.
- 为了比较各种eGFR方程与测量的GFR (mGFR) 的准确性.
主要方法:
- 包括慢性病患者和潜在的脏捐赠者.
- 使用尿清除胰岛素和IOhexol的血清除率来测量GFR.
- 对eGFR方程的评估 (CKD-EPICr(2021),CKD-EPICr-Cys(2021),CKD-EPICr(2009)等等) 是一个非常简单的方法. 使用偏差,精度和准确度指标 (RMSE,MAE,P30).
主要成果:
- 总共有412名受试者被录取,其中55%患有CKD.
- 基于肌素的EGFR方程显示了最高的偏差,显著高估了GFR.
- 基于赛斯塔丁C的方程显示了边际改善,但没有达到所需的准确度值 (P30 ≥80%).
结论:
- 在印度人中,种族中立的CKD-EPICr(2021)并没有超过较旧的CKD-EPICr(2009)等式.
- 对于开发和验证专门针对印度人口的新型eGFR方程的需求至关重要.
- 标准化mGFR测量对于个性化患者护理至关重要.
相关概念视频
01:02Renal Drug Excretion: Glomerular Filtration
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The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production occurs. A nephron has two main components: a renal corpuscle and a renal tubule.
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles....
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01:17Factors Affecting Renal Clearance: Renal Impairment
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Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
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01:23Renal Clearance
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The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
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01:28Glomerular Filtration Rate and its Regulation
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GFR regulation involves two primary intrinsic controls: the myogenic and tubuloglomerular feedback mechanisms.
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The myogenic...
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01:07Determination of Renal Drug Clearance: Graphical and Midpoint Methods
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Renal clearance, a crucial parameter in pharmacokinetics, can be determined using two different methods: the graphical method and the midpoint method. These methods provide insights into the rate of drug excretion by the kidneys and aid in assessing renal function.
The graphical method involves plotting the rate of drug excretion in urine against the plasma drug concentration. By analyzing the graph, the clearance can be calculated and obtained. Drugs rapidly excreted by the kidneys exhibit a...
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01:08Renal Drug Clearance: Comparison Between Renal Excretion Methods
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