性炎的长期结局 通过反应状态
Desmond Yat Hin Yap1, Xiaomeng Xu2, Patricia C Juliao3
1School of Clinical Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.
Kidney international reports
|December 19, 2024
概括
在患有狼性炎的中国患者中,在两年内达到修改反应标准显著改善了长期脏存活率,并减少了慢性脏病的进展.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
- 临床医学 临床医学
背景情况:
- 有限的数据存在临床试验响应标准的预测价值的亚洲患者与狼性炎 (LN) 的长期结果.
- 了解结局的预测因素对于管理这种自身免疫性病至关重要.
研究的目的:
- 评估2年治疗反应标准是否预测狼性炎的中国患者的长期脏存活率和慢性脏病 (CKD) 进展.
- 评估修改初级疗效反应 (mPERR) 和修改完整反应 (mCRR) 和长期结局之间的关联.
主要方法:
- 对176名中国成年患者的前性收集数据进行了回顾性分析,这些患者患有活检证明的狼性炎.
- 检查患者的mPERR和mCRR2年后,根据估计的淋巴细胞过率 (eGFR) 和尿蛋白与肌素比率 (uPCR) 进行了评估.
- 在平均随访15.3年后,分析了2年反应状态与长期脏存活率和CKD阶段 (≥3) 之间的关联.
主要成果:
- 在2年后,64.2%的人达到mPERR,43.8%的人达到mCRR.
- 与非响应者相比,mPERR和mCRR响应者表现出明显更高的长期脏存活率 (mPERR: 85.8%与71.4%相比;mCRR: 92.2%与71.7%相比).
- 实现mPERR和mCRR与脏不存活的风险 (分别为60%和86%) 和CKD阶段≥3 (分别为82%和87%) 的显著降低有关.
结论:
- 在患有狼性炎的中国患者中,在剖析后2年实现mPERR或mCRR是优越长期结局的强有力的预测指标.
- 这些反应标准与显著降低功能衰竭和进展到晚期慢性病的风险有关.
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