在代谢功能障碍相关的脂肪性肝病中,睡眠开始后显著的夜间清醒
Sofia Schaeffer1,2, Andrijana Bogdanovic1, Talitha Hildebrandt1
1Department of Biomedicine and Department of Clinical Research, University of Basel, Basel, Switzerland.
Frontiers in network physiology
|December 19, 2024
概括
患有代谢功能障碍相关的脂肪性肝病 (MASLD) 的患者经历了碎片化的睡眠,包括更多的夜间觉醒和更低的睡眠效率. 一个单一的睡眠卫生教育课程并没有改善这些睡眠障碍.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一种由饮食,环境和遗传学影响的复杂疾病.
- 循环失调和睡眠障碍与MASLD的发病有关,影响肝脏代谢.
- 以前的研究表明,MASLD患者的睡眠和清醒中断,需要客观评估.
研究的目的:
- 与健康对照人群相比,客观地评估活检证明的MASLD患者的睡眠-清醒节奏.
- 调查睡眠碎片化对MASLD睡眠质量的影响.
- 评估单次睡眠卫生教育课程在改善MASLD患者睡眠参数方面的有效性.
主要方法:
- 在35名MASLD患者和16名健康对照中,客观评估睡眠-清醒节奏,使用24小时24小时的4周的动图.
- 在基线数据收集2周后提供标准化睡眠卫生教育.
- 组间对动图学衍生睡眠参数 (唤醒,入睡后的清醒,睡眠效率,睡眠持续时间) 和主观睡眠质量报告进行比较.
主要成果:
- 与对照组相比,MASLD患者在夜间醒来次数显著增加 (8.5比5.5,p=0.0036) 和入睡后的清醒时间更长 (45.4分比21.3分,p=0.0004).
- 在MASLD患者中,睡眠效率降低 (86.5%对92.8%,p=0.0008),尽管总睡眠时间相似.
- MASLD患者报告睡眠时间较短和睡眠延迟时间较长,这表明主观睡眠质量较差. 睡眠卫生教育没有显著改善.
结论:
- 患有MASLD的患者在客观上经历了夜间睡眠的碎片化,其特点是觉醒增加和睡眠效率降低.
- 关于睡眠时间缩短和睡眠开始延迟的主观报告与睡眠质量差的客观发现一致.
- 单次睡眠卫生教育不足以改善MASLD患者的睡眠参数,这表明需要更密集的干预措施.
更多相关视频
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
1.1K
04:14Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution
Published on: April 16, 2019
11.9K
相关概念视频
Sleep-Wake Cycles
1.2K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.2K
Narcolepsy
89
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
89
Restless Leg Syndrome and Night Terrors
149
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
149
REM Sleep Behavior Disorder
143
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
143
Insufficient Sleep and Sleep Deprivation
133
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
Sleep deprivation is a more severe form of sleep loss...
133
