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Updated: Jun 4, 2025

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A Free-breathing fMRI Method to Study Human Olfactory Function
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在患有创伤性嗅觉障碍的患者中,主观嗅觉功能障碍的特征和成像特征:一个回顾性病例控制研究
Baihan Su1,2,3,4,5, Xing Gao6, Peng Lin1,2,3,4,5
1Department of Otorhinolaryngology Head and Neck Surgery, Tianjin First Central Hospital, Tianjin, China.
Quantitative imaging in medicine and surgery
|December 19, 2024
概括
与其他嗅觉障碍相比,创伤性嗅觉障碍显著损害了嗅觉功能,并减少了与其他嗅觉障碍相比关键大脑区域的灰色和白质体积. 这些大脑变化可以帮助诊断头部创伤后的嗅觉丧失.
科学领域:
- 神经学 神经学
- 神经成像是一种神经成像.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 头部创伤后的嗅觉功能障碍由于直接脑损伤而带来诊断和治疗挑战.
- 目前的成像缺乏标准化的标准来诊断创伤性嗅觉功能障碍.
- 这项研究将创伤患者的嗅觉功能和大脑物质量与其他嗅觉功能障碍组进行比较.
研究的目的:
- 为了比较创伤性嗅觉功能障碍和其他嗅觉功能障碍类型的患者之间的主观嗅觉功能和大脑灰质 (GM) 和白质 (WM) 体积差异.
- 识别与创伤性嗅觉障碍相关的成像特征.
- 为诊断创伤性嗅觉功能障碍提供基础.
主要方法:
- 一项追溯病例控制研究,涉及56名创伤性嗅觉功能障碍患者和45名其他嗅觉功能障碍患者.
- 使用"嗅棒"测试评估的主观嗅觉功能.
- 脑的GM和WM体积使用基于voxel的形态测量 (VBM) 进行比较.
主要成果:
- 与对照组相比,创伤组的嗅觉功能得分 (总和子测试) 显着较低.
- 在创伤组中观察到减少的GMV和WMV,包括轨道前皮层,前带带状回,胰岛和嗅觉皮层在内的区域.
- 在特定的大脑区域的气味识别得分和GMV之间发现了积极的相关性,这些区域在创伤组中减少了.
结论:
- 与其他类型的嗅觉功能障碍患者相比,创伤性嗅觉功能障碍患者的嗅觉功能较差,脑部结构损伤更严重.
- 特定的大脑区域的损伤,包括轨道前皮层和嗅觉皮层,是创伤性嗅觉障碍的特征.
- 这些已识别的大脑区域的嗅觉神经损伤可以作为创伤性嗅觉障碍的诊断基础.
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