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Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...

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Batch Immunostaining for Large-Scale Protein Detection in the Whole Monkey Brain
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通过免疫组织化学检测麻疹病毒

Spencer Ng1, Carla Stephan2, Mytrang Do3

  • 1Division of Dermatology, Department of Medicine, and Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Journal of cutaneous pathology
|December 19, 2024
PubMed
概括
此摘要是机器生成的。

一种新的单克隆抗体测试可以在皮肤病变中准确检测麻疹病毒 (MPXV). 这种免疫组织化学 (IHC) 染色剂有助于在其他方法无法确定时确认mopox诊断.

关键词:
免疫组织化学 免疫组织化学传染病是一种传染性疾病.的水是的水.这是一种单克隆抗体.麻疹病毒 (poxvirus) 是一种病毒.病毒感染 病毒感染

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科学领域:

  • 病毒学 病毒学
  • 皮肤病学 皮肤病学
  • 免疫组织化学 免疫组织化学

背景情况:

  • 麻疹病毒 (Monkeypox virus - MPXV) 爆发,出现特征性的皮肤病变.
  • 莫波克斯病变的组织病理学显示表皮亡,皮肤,和病毒细胞病变的变化.
  • 传统的mopox诊断方法可能是不特定的.

研究的目的:

  • 评估单克隆抗体对免疫组织化学 (IHC) 染色的有用性,以确认mopox感染.
  • 评估抗体对其他病毒感染的特异性.

主要方法:

  • 用单克隆MPXV特异性抗体 (向A29) 染色了PCR确认的三个mopox患者活检.
  • 对照样本包括具有其他MPXV抗原的细胞系和来自Molluscum contagiosum,简单疹,疹和细胞巨病毒感染的皮肤活检.

主要成果:

  • 针对MPXV的特定抗体可靠地检测出了所有三个mopox患者活检中的病毒感染.
  • 在mopox病变中观察到分散的细胞质和焦点核染色模式.
  • 在对照细胞系或其他病毒感染的活检中没有发生染色,这表明特异性很高.

结论:

  • 一个单克隆的MPXV特异性抗体是确认mopox感染的宝贵辅助工具.
  • 用这种抗体进行IHC染色为皮肤病变中诊断mpox提供了一种特定的方法.