唐氏综合征和同时发生的自闭症谱系障碍的适应性和行为特征:一个案例对照研究
Elisa Fucà1, Stefano Vicari1,2, Floriana Costanzo1
1Child and Adolescent Neuropsychiatry Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
概括
患有唐氏综合征 (DS) 和自闭症谱系障碍 (ASD) 的儿童表现出较低的适应能力和增加的社会退缩. 早期发现ASD对于个性化干预至关重要.
科学领域:
- 神经发育障碍 神经发育障碍
- 遗传学 遗传学是一种遗传学.
- 儿科神经学 儿科神经学
背景情况:
- 唐氏综合症 (DS) 是智力障碍 (ID) 的主要遗传原因.
- 患有DS的人患神经发育障碍的风险更高,包括自闭症谱系障碍 (ASD).
研究的目的:
- 调查儿童和青少年与DS同时发生的ASD临床特征.
- 将DS和ASD个体之间的适应性和行为概况与只有DS的个体进行比较.
主要方法:
- 一项病例对照研究将DS和ASD (ASD组) 的参与者与只有DS的年龄,性别和智商匹配的参与者 (CON组) 进行了比较.
- 评估适应能力和行为症状.
主要成果:
- 与CON组相比,ASD组的适应能力明显较低,即使与适度/严重智力障碍相匹配.
- 在内化或外化行为方面没有发现显著差异.
- 自闭症组的参与者表现出更高水平的社会退缩,刻板印象的行为和受限制的兴趣.
结论:
- 高度的刻板印象行为和受限制的兴趣可以帮助检测ASD在DS患者中同时发生的ASD.
- 在这个人群中,仪式式的行为或坚持同样性可能并不强烈地表明ASD.
- 自闭症加剧了智力障碍的影响之外的自适应性行为缺陷,强调了对日常生活技能的早期干预的需要.
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