"探索口腔平和 Xerostomia 之间的联系: 一个系统的文献评论"
Farzaneh AghaHosseini1,2,3, Maryam Tahmasebinasab4, Mehdi Vatanpour5
1Dental Research Center, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Immunity, inflammation and disease
|December 19, 2024
概括
口腔平坦 (OLP) 和口腔干燥 (xerostomia) 经常同时发生,研究表明OLP患者的唾液流量减少. 然而,OLP和口腔干燥之间的直接因果关系仍然未被证明.
科学领域:
- 口腔医学是指口腔医学.
- 唾液腺研究 唾液腺研究
- 免疫皮肤学 免疫皮肤学
背景情况:
- 口腔平坦 (OLP) 是一种慢性炎症状况,影响口腔粘膜.
- Xerostomia,或口腔干燥,是一种常见的症状,可以独立发生或与OLP一起发生.
- 大约45%的OLP患者,特别是那些有红血和的患者,报告口腔干燥的感觉.
研究的目的:
- 系统地审查现有关于异口症与OLP的关系和共发生的文献.
- 确定导致OLP患者口腔干燥的因素.
- 为开发OLP改进的管理策略提供信息.
主要方法:
- 按照PRISMA 2020指南进行系统审查.
- 包括在OLP患者中调查异口症的人类研究.
- 选了897篇文章,其中9项研究被选中进行分析.
- 使用Cochrane偏差风险工具进行质量评估 (ROB 2,ROBINS-I).
主要成果:
- 分析了1960年至2023年间发表的9项研究.
- 许多研究表明,OLP患者的非刺激唾液流率显著降低.
- 虽然存在相关性,但OLP和异口症之间没有确定的因果关系.
- 已确定的潜在的促成因素包括甘地菌感染,改变的唾液蛋白和炎症引起的神经损伤.
结论:
- 建议OLP和减少唾液产生的联系,但因果关系没有被证明.
- 存在显著的研究缺口,包括不一致的方法和缺乏标准化诊断标准在OLP.
- 未来的研究应该调查多种OLP亚型,受体相互作用,免疫反应和神经,以阐明OLP中异位素病原发生的原因.
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