在莫桑比克的马普托市,家禽微生物组和抵抗体的农场到叉的变化
Natalie Olson1, Frederica Lamar1, Hermógenes Mucache2
1Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
mSystems
|December 19, 2024
概括
莫桑比克的家禽市场是食物传播病原体和抗菌素耐药性基因的关键暴露点. 商用尸可能携带高风险的基因,这些基因并非来自便,这表明市场受到污染.
科学领域:
- 微生物学 微生物学
- 食品安全 食品安全
- 公共卫生 公共卫生
背景情况:
- 在低收入和中等收入国家,家禽生产正在增加,这带来了食物传播疾病和抗菌素耐药性的风险.
- 在这些环境中,有限的水,卫生和卫生基础设施加剧了传播风险.
- 通过环境途径暴露的儿童的暴露和肠道病原体 (ChEEP ChEEP) 研究在莫桑比克的马普托市调查了这些风险.
研究的目的:
- 在家禽供应链中量化肠道病原体和抗菌素耐药性基因暴露.
- 在商业与本地品种中对便和尸体微生物组和抵抗组进行表征.
- 确定关键控制点,以减少人类对病原体和抗菌素耐药性的暴露.
主要方法:
- 来自生产场所和市场的便,尸体和冲洗桶样本的元基因组测序.
- 分类学概况,以识别潜在的人类病原体.
- 抗微生物耐药性基因 (ARG) 鉴定,重点关注高风险的ARG.
- 多样性和社区结构分析 (α多样性,布雷-库蒂斯不相似性).
主要成果:
- 商业和当地在生产和市场场所表现出明显的便微生物组和抵抗组.
- 在市场的尸体上发现了潜在的致病细菌和来自便的ARG.
- 商业尸中含有高风险的ARG,但不存在便中,这表明市场受到污染.
- 露天市场被确定为人类暴露的重要地点.
结论:
- 禽类供应链,特别是市场,是传播肠道病原体和抗菌素耐药性基因的重要通道.
- 在商业和本地品种之间存在不同的微生物和抗体特征.
- 针对市场环境的干预措施对于减轻与家禽消费相关的公共卫生风险至关重要.
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