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Updated: Jun 6, 2026

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在光链逃脱之前和之后的单细胞RNA测序揭示了患者内多发性骨髓瘤亚种群与分歧的骨解基因表达

Denis Ohlstrom1,2, Zachary J Walker1, Abhishek Pandey3

  • 1Division of Hematology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Cancer research communications
|December 19, 2024
PubMed
概括

多发性骨髓瘤中的轻链逃逸 (LCE) 源于不同的恶性细胞亚群. 这种进化与LAMP5基因过度表达有关,预测骨解性骨病和不良预后.

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相关概念视频

Ribosome Profiling02:24

Ribosome Profiling

Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique helps...