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相关概念视频

Synthesis and Regulation of Thyroid Hormones01:20

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Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
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Functions of Thyroid Hormones01:18

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
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The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
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Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
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Target Cell Response to Hormones01:22

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Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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相关实验视频

Updated: Jun 4, 2025

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
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甲状腺激素和肝脏的作用

Lorraine Soares De Oliveira1, Megan J Ritter

  • 1Department of Medicine, Boston University Chobanian & Avedisian School of Medicine, Boston Medical Center, Boston, Massachusetts, USA.

Hepatology communications
|December 19, 2024
PubMed
概括
此摘要是机器生成的。

甲状腺激素 (TH) 影响肝脏代谢,其受体THRβ是关键的. 这篇评论探讨了TH的研究.

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科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 内分泌学 在内分泌学.
  • 代谢疾病 代谢疾病

背景情况:

  • 甲状腺激素调节肝脏的关键代谢途径,包括胆固醇代谢,脂质生成和脂肪酸氧化.
  • 甲状腺激素受体β (THRβ) 是肝脏中的主要异型,介导甲状腺激素的作用.
  • 甲状腺功能低下症与脂质不良症和代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有关.

研究的目的:

  • 探索甲状腺激素,肝功能和MAFLD之间的复杂关系.
  • 审查目前对涉及甲状腺激素类似物的MAFLD的治疗策略.
  • 确定基于甲状腺激素的MAFLD治疗的未来研究方向.

主要方法:

  • 关于甲状腺激素和肝脏代谢现有研究的文献综述.
  • 关于甲状腺激素失调和MAFLD的临床数据的分析.
  • 检查甲状腺激素受体 (THR) 异型和辅调剂的作用.

主要成果:

  • 甲状腺激素在维持肝脏代谢平衡中起着至关重要的作用.
  • 甲状腺激素类似物,如resmetirom,在治疗MAFLD方面表现有前途.
  • 甲状腺激素的失调有助于MAFLD和相关的脂质失调症的发病.

结论:

  • 甲状腺激素是肝脏新陈代谢的关键调节者,也是MAFLD的潜在治疗点.
  • 甲状腺激素类似物代表了管理MAFLD的新治疗途径.
  • 需要进一步的研究,以充分阐明针对肝脏疾病中的甲状腺激素途径的治疗潜力.