寨卡病毒感染和急性横脊髓炎:一个全面的系统审查
Bianca Aparecida Colognese1, Nayara Argollo1
1Universidade Federal da Bahia, Hospital Universitário Professor Edgard Santos, Salvador, Bahia, Brazil.
Revista do Instituto de Medicina Tropical de Sao Paulo
|December 19, 2024
概括
寨卡病毒 (ZIKV) 感染可能导致急性横侧髓炎 (ATM),这是一种罕见的脊髓炎症. 这篇评论详细介绍了ATM的细节.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 寨卡病毒 (ZIKV) 与神经系统并发症有关,包括急性横侧髓炎 (ATM).
- 临床特征和ZIKV相关的ATM和特异性ATM之间的区别仍然不完全理解.
- ATM涉及运动,感官和自主功能障碍的快速发作.
研究的目的:
- 系统地审查文献的临床特征,诊断检查,治疗和预后的ATM在ZIKV感染后的预后.
- 分析ATM病例,无论是单独的还是与其他神经疾病 (混合疾病) 相结合.
主要方法:
- 在五个数据库中进行系统的文献搜索.
- 遵守系统审查和元分析 (PRISMA) 准则的首选报告项目.
- 包括包括20个主题的9篇文章.
主要成果:
- 受ZIKV相关ATM影响的主要年龄组为20-30岁.
- 混合疾病的中位预发期为2天,孤立的ATM为7天.
- 超过50%的患者经历了中度至重度的残疾,这表明可能出现重大后果.
结论:
- 与特异性ATM相比,与ZIKV相关的ATM呈现出明显的临床特征和前兆期.
- 混合疾病组显示共感染的发病率更高.
- 及时诊断和治疗至关重要,特别是在流行地区,以减轻严重的后果和长期残疾.
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