第二个和第三个三个月初的母亲细胞因子概况不能预测早产
Kylie K Hornaday1, Nikki L Stephenson2, Mary T Canning3
1Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta, Canada.
PloS one
|December 19, 2024
概括
孕产妇的炎症性细胞因子在早产子类型中表现出不同的模式. 虽然TNFα在妊娠期间的变化可以预测医学上指示的早产,但其他生物标志物对于自发早产缺乏预测性临床价值.
科学领域:
- 生殖生物学 生殖生物学
- 免疫学 免疫学 免疫学
- 围产儿医学 围产儿医学
背景情况:
- 过早分娩仍然是新生儿发病率和死亡率的主要原因.
- 之前对母亲炎症性细胞因子和早产的研究已经产生了不一致的结果.
- 有限的研究存在于纵向细胞因子趋势及其与特定早产子类型的关联.
研究的目的:
- 为了调查整个妊娠期间母亲循环的炎症性细胞因子和生长因子水平.
- 探索这些生物标志物与早产子类型之间的关联:自发早产 (sPTL),早产前膜破裂 (PPROM) 和医学上指示的早产 (mPTB).
主要方法:
- 从15种炎症性细胞因子和生长因子中采集了血和血清样本,分别在两个时间点:第二 trimester (17-23周,T1) 和第三 trimester (28-32周,T2).
- 生物标志物水平与自发早产 (sPTL),早产前膜破裂 (PPROM) 和医学上指示的早产 (mPTB) 相比,与到期出生进行了分析.
主要成果:
- 在T2和T1之间瘤坏死因子α (TNFα) 水平的变化从出生到期 (AUC = 0.79) 显著地归类为医学上指示的早产 (mPTB).
- 升高的可溶性细胞间粘附分子-1 (sICAM-1) 水平与自发早产 (sPTL) 有显著关联,但它不是一个有效的预测生物标志物.
- 观察到TNFα和sICAM-1的统计差异,但被认为对预测没有临床意义.
结论:
- 循环的孕产妇炎症生物标志物似乎与自发的早产没有可靠的关系.
- 在不同类型的早产之间可能存在不同的炎症特征.
- 虽然一些生物标志物显示了统计学关联,但它们在预测早产子类型的临床实用性有限.
相关概念视频
Development of Immunocompetence
283
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
283
Transcytosis of IgG
2.7K
Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...
2.7K
Oogenesis
63.4K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.4K


