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相关概念视频

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

450
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
450
Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation01:22

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
141
Liver Physiology01:30

Liver Physiology

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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
419
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

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Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
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相关实验视频

Updated: Jun 4, 2025

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
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轻微升高的肝转氨酶水平:原因和评估

Robert C Langan1, Kourtni A Hines-Smith1

  • 1St. Luke's Family Medicine Residency-Sacred Heart Campus, Allentown, Penn.

American family physician
|December 19, 2024
PubMed
概括

升高的肝酶,阿斯巴酸和氨酸转胺酶,影响10-20%的人. 常见的原因包括与代谢功能障碍相关的脂肪性肝病 (MASLD) 和酒精,生活方式的改变对管理至关重要.

科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 内部医学 内部医学
  • 生物化学 生物化学

背景情况:

  • 肝脏化学水平升高,包括阿斯巴酸盐和氨酸氨基酶,在10-20%的普通人群中观察到.
  • 这些升高可以表明严重的肝病,并与增加的死亡风险有关.
  • 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和酒精性肝病是轻微升高的转氨基酶的最常见原因.

研究的目的:

  • 概述高氨酸酶水平的常见和不常见原因.
  • 描述肝脏疾病的初始实验室检测和诊断方法.
  • 强调生活方式的改变和潜在的纤维化评估,以控制肝酶的升高.

主要方法:

  • 综述常见,不常见和罕见的转氨基酶升高的原因.
  • 描述最初的实验室调查,包括血细胞计数,代谢面板和病毒性肝炎查.
  • 提到纤维化评分系统,如FIB-4和NAFLD纤维化评分用于MASLD评估.

主要成果:

  • MASLD和酒精性肝病是轻微升高的转氨基酶的主要驱动因素.
  • 一系列的疾病,从乙型肝炎和血液染色症到自身免疫性疾病和肝外原因,也可能导致水平升高.
  • 最初的测试指导了进一步的调查,纤维化得分有助于对MASLD的风险分层.

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相关实验视频

Last Updated: Jun 4, 2025

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结论:

  • 由于它们与肝脏疾病和死亡率的关联,迅速识别和管理高氨基酶是必不可少的.
  • 生活方式干预,如酒精适度,减肥,避免肝毒药物是基本的.
  • 对于有重大肝纤维化风险的患者,需要进一步调查和专家转诊.