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Updated: Jun 4, 2025

Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps
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Author Spotlight: Exploring Cellular Processes by Modeling Ligands in Cryo-EM Maps

Published on: July 19, 2024

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在使用深度学习的CryoEM和X射线图中识别连接物.

Jacek Karolczak1, Anna Przybyłowska1, Konrad Szewczyk1

  • 1Institute of Computing Science, Poznan University of Technology, Poznan 60-965, Poland.

Bioinformatics (Oxford, England)
|December 19, 2024
PubMed
概括

我们开发了一种深度学习方法,从3D点云密度图中识别连接物. 这种方法适用于X射线晶体学和冷电子显微镜 (cryoEM),与现有的X射线数据方法相匹配.

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相关概念视频

Cryo-electron Microscopy01:28

Cryo-electron Microscopy

Conventional electron microscopy (EM) involves dehydration, fixation, and staining of biological samples, which distorts the native state of biological molecules and results in several artifacts. Also, the high-energy electron beam damages the sample and makes it difficult to obtain high-resolution images. These issues can be addressed using cryo-EM, which uses frozen samples and gentler electron beams. The technique was developed by Jacques Dubochet, Joachim Frank, and Richard Henderson, for...
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