基于Eu-tungstate复合体的红色发射光传感器用于检测生物流体中的 bilirubin
Ali Ibrahim Shkhair1, Anju S Madanan2, Susan Varghese2
1Department of Chemistry, School of Physical and Mathematical Sciences, University of Kerala, Kariavattom Campus, Thiruvananthapuram 695581, Kerala, India; College of Food Science, Al-Qasim Green University, Babylon 51013, Iraq.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
|December 19, 2024
概括
一种新的欧欧-酸复合物提供了一种敏感的"关闭"发光方法,用于检测黄的关键生物标志物胆红素,在人类尿液和血清样本中.
科学领域:
- 分析化学 分析化学
- 生物标志物检测检测 生物标志物检测
- 材料科学 材料科学 材料科学
背景情况:
- 胆红素是评估人类健康新陈代谢的关键生物标志物,特别是在诊断黄时.
- 精确和敏感的胆红素检测对于临床诊断和监测至关重要.
研究的目的:
- 开发一种基于欧欧-酸盐复合物的新型发光测定,用于胆红素检测.
- 评估这种方法在人类生物样本中的效率和适用性.
主要方法:
- 在环境温度下通过单程序合成稳定的欧-酸复合物.
- 基于胆红素与复合体相互作用的"关闭"发光检测策略的开发.
- 使用人类尿液和血清样本验证该方法.
主要成果:
- 合成的欧-酸复合体显示强烈的红色发射和高稳定性.
- 复合体的发光被 bilirubin 灭,从而可以进行定量检测.
- 达到了0.27μM的检测极限 (LoD) 和0.91μM的胆红素定量极限 (LoQ).
- 在真实的人体样本中成功应用传感技术.
结论:
- 开发的欧-酸复合体为胆红素检测提供了一个敏感而稳定的平台.
- 这种基于发光的方法为治疗黄的临床诊断提供了有前途的方法.
- 该方法在真实样本中的有效性突显了其实际实用性.
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