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Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.

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开发多孔部植入物,实现基于骨改造模型和疲劳失败模型的拓优化.

Babak Ziaie1, Xavier Velay2, Waqas Saleem3

  • 1Department of Mechanical and Manufacturing Engineering, Atlantic Technological University, Ash Lane, Sligo, F91 YW50, Ireland; Centre for Precision Engineering Material and Manufacturing Research (PEM Research Centre), Atlantic Technological University, Ash Lane, Sligo, F91 YW50, Ireland; Centre for Mathematical Modelling and Intelligent Systems for Health and Environment (MISHE), Atlantic Technological University, Ash Lane, Sligo, F91 YW50, Ireland.

Journal of the mechanical behavior of biomedical materials
|December 19, 2024
PubMed
概括

多孔部植入物可以减轻由固体植入物引起的应激屏蔽和骨再吸收. 渐变的多孔设计提供机械强度和生物效益,使它们成为全关节整形手术的前景.

关键词:
增材制造 增材制造是一种增材制造.骨头重塑 骨头的重塑对于女性来说,FEM就是女性.疲劳失败导致的疲劳失败毛孔植入物是一种多孔植入物.这是一个TPMS系统.拓优化优化拓的优化

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科学领域:

  • 生物材料工程 生物材料工程
  • 整形外科手术 整形外科手术
  • 计算力学 计算力学 计算力学

背景情况:

  • 固体全关节整形术 (THA) 植入物可能会导致应力屏蔽和皮层缩,原因是机械与骨不匹配.
  • 多孔植入物提供可调节的机械性能,可能减少与固体植入物相关的并发症.

研究的目的:

  • 开发和评估多孔部植入物使用拓优化解决应力屏蔽.
  • 在生理负荷下比较固体,均多孔和梯度多孔植入物的机械性能.

主要方法:

  • 有限元分析 (FEA) 用于模拟不同植入物设计的骨应力分布.
  • 穿孔植入物的设计使用三次周期的最小表面结构 (例如,陀螺,钻石) 具有均和梯度的相对密度.
  • 考虑增材制造和生物约束的拓优化.

主要成果:

  • 固体植入物显著降低皮质骨压力,导致应激屏蔽.
  • 与固体植入物相比,均和渐变多孔植入物增加了拉伸能量密度比率 (均的陀螺和渐变钻石分别增加了43%和25%).
  • 只有渐变多孔植入物设计才能满足机械强度要求 (安全系数>1).

结论:

  • 渐变多孔植入物有效减轻压力屏蔽并保持骨健康.
  • 拓优化的梯度多孔植入物是固体THA植入物的合适替代品.
  • 增材制造方面的进步使得这些有前途的多孔植入物能够精确地制造.