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瘤透性淋巴细胞 (TILs) - 病理学,什么情况? - 一项全球调查调查

Kristijan Skok¹, Konstantin Bräutigam²

¹Diagnostic and Research Institute of Pathology, Medical University of Graz, Stiftingtalstraße 6, Graz 8010, Austria; Institute of Biomedical Sciences, Faculty of Medicine, University of Maribor, Taborska Ulica 8, Maribor 2000, Slovenia.

Pathology, research and practice

|December 19, 2024

概括

大多数病理学家不经常评估瘤透淋巴细胞 (TILs),尽管它们在癌症免疫治疗中的重要性. 实施中的挑战和对基于人工智能的量化偏好凸显了对人工智能工具和共识指南的需求.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

瘤透淋巴细胞 (TIL) 和瘤微环境在癌症研究和免疫治疗中至关重要.
病理学家在TIL评估中发挥着关键作用,但其常规实施不一致.

研究的目的:

评估TIL评估在病理学家常规临床实践中的当前使用和挑战.
确定TIL实施的障碍,并探索对评估方法的偏好.

主要方法:

2024年6月,通过社交媒体和电子邮件向病理学家分发了一项全球调查.
在恶性黑色素瘤和结直肠癌 (CRC) 中对TIL进行了文献审查.
分析了来自24个国家的77名参与者的调查数据.

主要成果:

超过一半的参与病理学家不定期评估或报告TILs.
对TIL报告的方法各不相同,从手动估计到基于AI的算法.
参与者发现TIL评估耗时,他们更喜欢人工智能驱动的量化.

结论:

职业生涯早期的病理学家认识到TIL的重要性,但面临实施障碍.
建议开发人工智能工具和共识指南,以改善TIL评估.
提高病理学家在TIL评估中的作用的可见性至关重要.

关键词:

结肠直肠癌是一种癌症.黑色素瘤是一种黑色素瘤.调查调查调查调查治疗疗法治疗疗法瘤微环境 (TME) 是指瘤的微环境.瘤透性淋巴细胞 (TILs) 是一种

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