动脉旋转标签在肌缩侧面硬化症中的现有证据:系统性审查
Sadegh Ghaderi1, Sana Mohammadi2, Farzad Fatehi3
1Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Neuromuscular Research Center, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
动脉旋转标签 (ASL) 在肌缩侧面硬化症 (ALS) 患者中显示脑血流 (CBF) 减少,甚至在结构变化出现之前. 这种技术可能有助于在早期诊断ALS和跟踪疾病进展.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 生物标志物发现发现
背景情况:
- 肌缩侧面硬化症 (ALS) 是一种进展性神经退行性疾病.
- 了解ALS中神经血管功能障碍对于早期诊断和管理至关重要.
研究的目的:
- 评估动脉旋转标签 (ASL) 评估脑血流 (CBF) 在ALS的变化.
- 确定ASL作为ALS早期诊断生物标志物的潜力.
主要方法:
- 在遵守PRISMA指南的基础上进行系统审查.
- 包括比较ALS患者与健康对照者的ASL测量CBF的研究.
主要成果:
- 在7项研究中,ALS患者的运动和非运动区域,特别是前皮质,呈现出一致的低流.
- 运动区域的低流与功能障碍相关,并且之前有结构变化,表明早期生物标志物潜力.
- 有限的证据表明,ASL可以监测不断演变的CBF模式,显示初始超,随后是渐进的低.
结论:
- 动脉旋转标签 (ASL) 是一种有前途的工具,可以帮助我们了解ALS中神经血管功能障碍.
- 需要进一步的研究来验证ASL对ALS诊断和疾病进展监测的临床实用性.
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