环境高温 (热中风) 在体内和体外造成关节软骨损伤
Sun Yingfei1, Yang Feng1, Ma Haoning1
1Spinal surgery, China-Japan Friendship Hospital, East Ying Hua Yuan Street, Chaoyang District, Beijing, China.
Ecotoxicology and environmental safety
|December 19, 2024
概括
热中风通过诱导状细胞PANoptosis显著损害关节软骨. 纤维细胞生长因子21 (FGF21) 显示出减轻热中风引起的软骨损伤的潜力.
科学领域:
- 生物医学科学 生物医学科学
- 环境健康 环境健康
- 整形外科 整形外科 整形外科
背景情况:
- 全球变暖趋势与热中风 (HS) 发生率的增加相关.
- 热中风是一个日益严重的公共卫生挑战.
- 热中风对关节软骨的病理影响在很大程度上仍然未被描述.
研究的目的:
- 在体外和体内研究热中风对软骨细胞和关节软骨的影响.
- 阐明热中风引起的软骨损伤背后的分子机制.
- 评估FGF21在减轻热中风诱导的冠状细胞损伤方面的治疗潜力.
主要方法:
- 在体外测试中对胆细胞进行研究,评估细胞活性,线粒体膜潜力和氧化应激.
- 生物化学分析以确定细胞死亡途径 (PANoptosis).
- 使用免疫组织化学和分子分析 (ZBP-1通路) 在体内评估关节软骨损伤.
- 评估FGF21对热中风诱导的冠状细胞损伤的影响及其通过AMPK信号传递的机制.
主要成果:
- 热中风降低了状细胞的活动,降低了线粒体膜潜力,并诱导了氧化应激.
- 热中风触发了冠状细胞中的PANoptosis,由ZBP-1介导.
- 在体内,热中风对关节软骨造成了显著的损伤,包括编程性亡.
- FGF21通过减轻热中风诱导的状细胞泛亡,部分通过AMPK激活,显示出保护作用.
结论:
- 热中风会导致关节软骨通过冠状细胞PANoptosis受到重大损伤.
- 热中风引起的软骨损伤中,ZBP-1 是一个关键的媒介.
- 通过通过AMPK信号调节PANoptosis,FGF21为热中风相关的软骨损伤提供了一个潜在的治疗策略.
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