腹腔大动脉动脉瘤的动力学
Mostafa Jamshidian1, Adam Wittek1, Saeideh Sekhavat1
1Intelligent Systems for Medicine Laboratory, The University of Western Australia, Perth, Western Australia, Australia.
Journal of biomechanics
|December 19, 2024
概括
本研究介绍了一种基于图像的方法,用于分析腹腔大动脉动脉瘤 (AAA) 壁的运动和应变,使用4D-CTA扫描. 非侵入性方法准确地测量了AAA动力学,与健康的动脉相比,揭示了较低的菌株.
科学领域:
- 生物医学工程 生物医学工程
- 医疗成像医学成像
- 心血管研究研究心血管研究
背景情况:
- 腹腔大动脉瘤 (AAA) 的生物力学对于了解疾病进展至关重要.
- 现有的研究主要集中在AAA壁应力上,对AAA动力学的研究有限.
- 包括墙壁位移和应变在内的AAA动力学提供了重要的生物力学见解.
研究的目的:
- 为AAA动力学分析提供基于图像的,针对患者的,体内和非侵入性的方法.
- 使用4D-CTA测量心脏周期期间AAA壁位移和应变.
- 将AAA壁应变与健康的大动脉壁应变进行比较.
主要方法:
- 使用规范化的可变形图像注册来估计4D-CTA的墙壁位移.
- 计算局部墙壁应变为正常位移与局部曲率半径的比.
- 采用了局部表面配件,用于估计曲率半径的非决定性异常值检测.
- 通过从有限元素生物力学模型中获得的合成数据验证了方法.
主要成果:
- 将该方法应用于十名患者,评估AAA壁位移和菌株.
- 周围壁拉伸 (第99百分位) 范围为2.62%至5.54% (平均4.45%,SD 0.87%). 周围墙拉伸 (第99百分位) 范围为2.62%至5.54% (平均4.45%,SD 0.87%)
- 与健康的大动脉组织相比,观察到明显较低的AAA壁菌株.
结论:
- 开发的基于图像的方法准确地测量了AAA壁位移,并使可靠的应变估计成为可能.
- 这种非侵入性的动力学分析为AAA提供了有价值的生物力学见解.
- 这些发现突出了AAA和健康的大动脉之间的壁应变差异,有助于理解AAA病理生理学.
相关概念视频
The Aorta
637
The aorta is the largest artery in the human body. It originates from the left ventricle of the heart and extends down to the abdomen, where it splits into two smaller arteries. Structurally, it can be divided into four main parts: the ascending aorta, the aortic arch, the thoracic aorta, and the abdominal aorta.
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...
The average diameter of the aorta is approximately 2-3 cm, but the size can vary depending on the section of the aorta and the individual's age, sex, and body size. The aorta is...
637
Abdominal Aorta
621
Once the aorta traverses the diaphragmatic plane at the aortic hiatus, it is known as the abdominal aorta. This anatomical structure is positioned leftward of the spinal column, encased within a cocoon of adipose tissue behind the peritoneal cavity. It terminates at the L4 vertebra, where it splits into the common iliac arteries. Prior to this bifurcation, the abdominal aorta gives rise to several vital branches.
The celiac trunk, a singular artery, divides into the left gastric artery, which...
The celiac trunk, a singular artery, divides into the left gastric artery, which...
621
Relative Motion Analysis using Rotating Axes - Acceleration
322
Consider a component AB undergoing a linear motion. Along with a linear motion, point B also rotates around point A. To comprehend this complex movement, position vectors for both points A and B are established using a stationary reference frame. The absolute velocity of point B is determined by adding the absolute velocity of point A, the relative velocity of point B in the rotating frame, and the effects caused by the angular velocity within the rotating frame.
Time differentiation is...
Time differentiation is...
322
Kinematic Equations for Rotation
315
In mechanics, when one observes a rigid body in rotational motion with constant angular acceleration, it is possible to establish equations for its rotational kinematics. This process resembles how linear kinematics are dealt with in simpler motion studies.
For instance, imagine a point A on a rigid body engaged in circular motion. The translational velocity of this particular point can be calculated by taking the time derivatives of the displacement equation, which essentially measures the...
For instance, imagine a point A on a rigid body engaged in circular motion. The translational velocity of this particular point can be calculated by taking the time derivatives of the displacement equation, which essentially measures the...
315
Relative Motion Analysis - Acceleration
330
A slider-crank mechanism converts rotational motion from the crank into linear motion of the slider or vice versa. This mechanism consists of three main parts: the crank, the connecting rod, and the slider. The movement of the slider-crank is an example of general plane motion as the fluctuating angle between the crank and the connecting rod. Consider a segment AB where point A is at the end of the slider and point B is on the diametrically opposite end to point A, on a crack. The variance in...
330
Relative Motion Analysis - Velocity
341
A stroke engine has a slider-crank mechanism that converts rotational motion from the crank into linear motion of the slider or vice versa. This mechanism consists of three main parts: the crank, the connecting rod, and the slider.
When an external force is exerted, it sets the crank into a rotational movement. This, in turn, instigates the motion of the connecting rod, leading to what is referred to as a general plane motion. This process involves two key points - point A on the connecting rod...
When an external force is exerted, it sets the crank into a rotational movement. This, in turn, instigates the motion of the connecting rod, leading to what is referred to as a general plane motion. This process involves two key points - point A on the connecting rod...
341


