大气粒子物质与自闭症之间的相关性研究进展
Yaqian Xiao1,2,3, Wang Xiang1,2,3, Xuerui Ma1,2,3
1Cooperative Innovation Center of Industrial Fermentation, Ministry of Education & Hubei Province, Hubei University of Technology, Wuhan, Hubei, China.
Journal of applied toxicology : JAT
|December 19, 2024
概括
空气污染,特别是细颗粒物 (PM2.5) 和可吸入颗粒物 (PM10),越来越多地与自闭症谱系障碍 (ASD) 风险有关. 本综述探讨了包括神经炎症和突触损伤在内的机制,将PM暴露与ASD病原体联系起来.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 遗传学 是一个遗传学.
背景情况:
- 自闭症谱系障碍 (ASD) 的患病率正在全球范围内上升,特别是在工业化地区.
- 除了遗传,环境因素也与自闭症的发展有关.
- 颗粒物 (PM) 空气污染被怀疑是导致ASD的环境因素.
研究的目的:
- 审查与ASD相关的PM2.5和PM10的流行病学研究.
- 阐明ASD中PM暴露的致病机制.
- 检查ASD候选基因SHANK3在PM诱导的神经毒性的作用.
主要方法:
- 文献搜索和流行病学研究的分析.
- 对PM的信号通路和病原性机制对突触损伤和神经炎症的审查.
- 在动物模型和人体研究中分析PM的影响.
主要成果:
- 暴露于PM与ASD风险增加有关.
- 微粒素诱导神经炎症和突触损伤,有助于ASD的发病.
- 不同的PM类型表现出不同的作用点和对ASD发展的影响.
结论:
- 微粒子空气污染是ASD的重要环境风险因素.
- 了解PM诱导的神经毒性机制对于ASD预防和干预至关重要.
- 需要进一步的研究来完善评估方法和探索技术创新.
相关概念视频
Autism Spectrum Disorder
59
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
59
Attention-Deficit/Hyperactivity Disorder
38
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
38
Modeling in Therapy
46
Modeling, a key technique in therapy, uses observational learning to help clients acquire and practice new skills by watching therapists demonstrate desired behaviors. This approach, rooted in Albert Bandura's concept of vicarious learning, plays a significant role in therapeutic interventions for various psychological conditions, including social anxiety, ADHD, and depression.
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
Participant Modeling
Participant modeling involves therapists demonstrating calm and effective behaviors in...
46
Asthma-I: Introduction
2.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Asthma: Pathogenesis and Management
348
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
348


