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Updated: May 2, 2026

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在瘤抑制基因中双基因失活的泛癌分析确定KEAP1的致癌性为肺癌的预测生物标志物

Mark Zucker1, Maria A Perry2, Samuel I Gould3

  • 1Computational Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Cell
|December 19, 2024
PubMed
概括

瘤抑制基因 (TSG) 失活模式各不相同,有些需要双基损失. 这项研究揭示了TSG结合性预测癌症的发展和治疗反应,影响治疗策略.

关键词:
KEAP1 的使用情况克努德森的两个命中双性无活化双性损失癌症基因组学临床测序肺癌 肺癌胰腺癌预测生物标志物瘤抑制基因

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Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
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