利兹美胺在治疗甲基胺依赖方面:一个随机的,安慰剂控制的试验
Nadine Ezard1,2,3,4, Brendan Clifford1,2,3,4, Krista J Siefried1,2,3,4
1National Centre for Clinical Research on Emerging Drugs, University of New South Wales, Sydney, Australia.
Addiction (Abingdon, England)
|December 19, 2024
概括
在依赖性个体中,在12周的时间内,lisdexamfetamine减少了甲基胺的使用. 虽然最初的结果很弱,但持续使用显示显著下降,改善了治疗满意度.
科学领域:
- 成 药物 药物 药物 药物
- 心理药理学 心理药理学
- 临床试验 临床试验
背景情况:
- 甲基胺依赖是一个重要的公共卫生问题.
- 减少甲基胺使用与改善健康和福祉有关.
- 需要有效的药物治疗方法来治疗甲基胺依赖.
研究的目的:
- 评估lisdexamfetamine在减少甲基胺使用方面的疗效和安全性.
- 评估治疗满意度和与lisdexamfetamine相关的不良事件.
主要方法:
- 一个随机的,双盲的,安慰剂对照试验,涉及164名成年人与甲基胺依赖.
- 参与者接受了lisdexamfetamine或安慰剂15周 (包括12周的维持阶段).
- 主要终点是13周过去28天内使用甲基胺;次要结局包括在治疗期间使用和满意度.
主要成果:
- 在第13周,利兹美胺的益处证据较弱 (P=0.49).
- 然而,在12周的维持阶段,lisdexamfetamine组的使用日数显著减少 (P=0.005).
- 使用lisdexamfetamine,观察到更高的自我报告的治疗有效性 (OR=2.89) 和满意度 (OR=3.80). 恶心是一个已知的不良事件.
结论:
- 利斯德克萨姆胺似乎可以在12周的治疗期间减少甲基胺的使用.
- 在治疗的最后4周持续减少的证据是微弱的.
- 利斯德克萨姆胺可能是一个可行的选择,用于管理甲胺依赖,改善患者报告的结果.
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