在患有多发性硬化症的患者中,detrusor过度活跃和膀感觉之间的间隔对过度活跃膀症状的严重程度的作用
Claire Hentzen1, Camille Chesnel1, Philippe Lagnau1
1GRC 01, GREEN Group of clinical REsEarch in Neurourology, Sorbonne University, Hôpital Pitié-Salpêtrière, AP-HP, 75013 Paris, France.
The French journal of urology
|December 19, 2024
概括
在多发性硬化症患者中,detrusor过度活性 (DO) 影响膀感觉. 在第一次和强烈的排泄欲望之间减少的体积显著加剧了过度活跃的膀症状,特别是警告时间.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 神经学 神经学
背景情况:
- 多发性硬化症 (MS) 经常导致膀功能障碍,包括过度活跃的膀 (OAB).
- 了解膀感觉感知与OAB严重程度之间的关系对于管理多发性硬化症患者至关重要.
研究的目的:
- 在患有多发性硬化症 (PwMS) 的患者中调查膀感觉感知动力学,detrusor过度活动 (DO) 和OAB症状严重程度之间的关联.
主要方法:
- 一项回顾性研究包括202名PwMS通过囊泡测量进行尿动力学评估.
- 数据包括膀日记,尿液症状概况 (USP) 评分和膀感觉 (第一次欲排尿[FDV]和强烈欲排尿[SDV]).
- 计算了FDV和SDV (FDV-SDV) 之间的体积.
主要成果:
- 在51.5%的患者中,存在体过活性 (DO).
- 减少的FDV-SDV体积 (<50mL) 与DO显著相关 (27%对比5%,P<0.0001).
- 在囊泡测量过程中,DO与早期的感官知觉相关. 在没有DO的患者中,减少FDV-SDV体积与空洞频率增加,空洞体积增加和OAB得分提高有关,特别是关于警告时间.
结论:
- 在尿动力学研究中,detrusor过度活动显著影响了PwMS中的膀感觉感知.
- 在没有DO的情况下,减少FDV-SDV体积是导致OAB严重程度增加和预警时间缩短的关键因素.
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