长期暴露于最小风险剂量的会导致 epididymal脂肪组织的功能障碍和代谢障碍
Victor Enrique Sarmiento-Ortega1, Daniel Issac Alcántara-Jara1, Diana Moroni-González1
1Laboratory of Metabolomic and Chronic Degenerative Diseases, Physiology Institute, Meritorious Autonomous University of Puebla. Prol. de la 14 Sur 6301, Ciudad Universitaria, Puebla C.P. 72560, Mexico.
Toxicology and applied pharmacology
|December 19, 2024
概括
慢性 (Cd) 暴露,即使在最小的风险水平,也会导致大鼠外皮层脂肪组织的毒性. 这种环境污染物破坏了代谢功能,并导致疾病.
科学领域:
- 环境毒理学环境毒理学
- 代谢研究的研究.
- 脂肪组织生物学 脂肪组织生物学
背景情况:
- (Cd) 是一种危险的环境污染物,具有确定的最低风险水平.
- 长期暴露于Cd会在各种组织中引起毒性,但其对脂肪组织的影响还未得到充分研究.
- 脂肪组织在内分泌和代谢调节中起着至关重要的作用.
研究的目的:
- 调查慢性暴露在无可观测不良影响水平 (NOAEL) 和最低可观测不良影响水平 (LOAEL) 的剂量对皮层脂肪组织的毒性影响.
- 评估对成年雄性Wistar大鼠的代谢参数和脂肪组织功能的影响.
主要方法:
- 成年雄性Wistar大鼠在饮用水中暴露在化 (CdCl2) 中,持续15天至5个月.
- 评估的参数包括动物测量,血清和脂肪Cd度,氧化还原平衡,基因表达 (GLUT4,Nrf2),组织学,激素水平 (莱普,阿迪波涅丁),胰岛素耐药性,自由脂肪酸和葡萄糖耐受性.
主要成果:
- 无论是NOAEL和LOAEL剂量都导致脂肪细胞缩,血清和脂肪组织度增加.
- 虽然通过Nrf2上调维持了氧化还原平衡,但是瘦素增加了,而皮蛋白减少了.
- 尽管GLUT4表达高,脂肪胰岛素耐药性,脂溶和葡萄糖不耐受性都增加了.
结论:
- 长期暴露于,即使在最小的风险水平,也会诱导 epididymal 脂肪组织的毒性.
- 暴露会破坏脂肪组织的功能,导致诸如胰岛素耐药性和葡萄糖不耐受性等代谢障碍.
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