来自Torreya grandis坚果的水溶性多糖:结构特征和抗炎活性
Luping Yang1, Yunjie Hu1, Hongdan Deng1
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
International journal of biological macromolecules
|December 19, 2024
概括
托雷亚格兰迪斯坚果多糖 (TGP) 具有显著的抗炎特性. 成分TGP-0a有效降低炎症媒介和氧化应激,显示功能性食品和药品的潜力.
科学领域:
- 食品科学 食品科学 食品科学
- 生物化学 生化学
- 药理学 药理学 是一个学科.
背景情况:
- 在中国,托雷亚格兰迪斯坚果作为功能性食品被消费.
- 来自自然来源的多糖化合物正在探索其健康益处.
研究的目的:
- 为了研究Torreya grandis坚果多糖的结构特征 (TGP).
- 为了评估TGP组件的抗炎潜力.
主要方法:
- 用水提取和酒精沉来提取TGP.
- 通过净化,得到了三种异多多糖 (TGP-0a,TGP-2a,TGP-3a).
- 结构分析涉及NMR和甲基化;生物活性通过细胞测试进行评估.
主要成果:
- TGP-0a表现出最强大的抗炎活性.
- TGP-0a主要由线性α-1,4-葡萄糖和β-1,4-糖) 曼南区域组成.
- 通过降低iNOS和COX-2的调节,TGP-0a显著降低了促炎性细胞因子,氧化 (NO),活性氧物种 (ROS) 和炎症媒介.
结论:
- 托雷亚格兰迪斯坚果的多糖,特别是TGP-0a,具有强大的抗炎作用.
- TGP-0a有效地减轻了炎症和氧化应激.
- 作为功能性食品和制药应用中的天然抗炎剂,TGP-0a显示出前景.
相关概念视频
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01:27Glucose Transporters
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
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Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes: