含有Capparis spinosa L.提取物的酸盐水凝,用于抗微生物和抗氧化剂的伤口包裹应用
Peng Zhu1, Jianmeng Wu1, Zhipeng Chang1
1School of Chemical Engineering, Zhengzhou University, 100 Science Avenue, Zhengzhou 450001, PR China.
International journal of biological macromolecules
|December 19, 2024
概括
结合Capparis spinosa L.提取物 (CSL) 和氨酸盐 (SA) 的新型复合水凝显示出增强的抗氧化和抗菌特性. 这些生物相容的水凝对先进的伤口包裹应用具有有前途的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 材料科学 材料科学 材料科学
背景情况:
- 甲基酸盐 (SA) 水凝已被广泛用于生物医学用途.
- 结合天然提取物可以增强水凝的功能.
- 卡帕里斯·斯皮诺萨L.提取物 (CSL) 具有已知的抗氧化特性.
研究的目的:
- 为生物医学应用开发CSL和SA的新型复合水凝.
- 评估CSL/SA水凝的物理化学,抗氧化,抗菌和生物相容性特性.
- 评估这些水凝作为伤口带的潜力.
主要方法:
- 使用CSL,SA和化 (CaCl2) 合成复合水凝.
- 描述包括胀程度,水分保留,抗氧化活性和FTIR分析.
- 对大肠杆菌和黄金杆菌的抗菌疗效使用亚格盘扩散进行了测试.
- 生物相容性通过细胞毒性研究进行评估.
主要成果:
- 在CSL/SA水凝中,SEM揭示了一个多孔的3D结构.
- FTIR证实了CSL成功地被纳入水凝矩阵.
- 最大的胀程度达到765.89%在9%的CSL度.
- 观察到增强的抗氧化活性,显著的抗菌作用和加速的细胞增殖.
结论:
- 在生物医学应用中,CSL/SA复合水凝具有理想的特性.
- 水凝表现出优异的胀,抗氧化和抗菌能力.
- 这些发现突显了CSL/SA水凝作为有效的伤口带的潜力.
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