通过生物标志物探索奶酪摄入量对胆病的影响:孟德尔的随机化研究
Wenwen Yang1, Yanjiang Yang2, Rui Ji3
1The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China; Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou, China; Gansu Province Clinical Research Center for Digestive Diseases, The First Hospital of Lanzhou University, Lanzhou, China.
Journal of dairy science
|December 19, 2024
概括
消费奶酪显示出对胆结石形成 (胆结石病) 的保护作用. 这种饮食因素影响关键的代谢和炎症生物标志物,可能降低疾病风险.
科学领域:
- 营养流行病学 营养流行病学
- 遗传流行病学遗传流行病学
- 生物标记分析 生物标记分析
背景情况:
- 胆结石病 (胆结石病) 造成严重的健康负担.
- 饮食因素,如奶酪摄入量,被怀疑会影响胆病风险,但因果关系尚不清楚.
- 了解调解饮食影响的生物途径对于预防至关重要.
研究的目的:
- 调查奶酪摄入量与胆病风险之间的因果关系.
- 为了确定受奶酪消费影响的介导生物标志物.
- 阐明代谢和炎症途径在这种关联中的作用.
主要方法:
- 孟德尔随机化 (MR) 分析利用遗传变异作为奶酪摄入量的工具变量.
- 利用来自Open GWAS和FinnGen Biobank的大规模遗传和表型数据.
- 采用两步调解分析来评估生物标志物的作用.
主要成果:
- 奶酪摄入量显著影响几个关键生物标志物,包括阿波利波蛋白B,直接胆红素,C反应蛋白,cystatin C,IGF-1和性激素结合型球蛋白.
- 观察到奶酪消费对胆病风险有显著的保护作用 (OR = 0.624,P < 0.0001).
- 生物标志物被确定为显著的调解者,解释了奶酪摄入量对胆病的影响的2.13%至7.22%.
结论:
- 吃奶酪似乎可以因果性地降低患胆结石的风险.
- 由特定生物标志物介导的代谢和炎症途径与奶酪的保护作用有关.
- 需要对不同种群进行进一步的研究来证实这些发现并探索机制.
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