[根据"辅助剂与草药之间的相互作用和组件转化"的动态处理,处理Aconiti Lateralis Radix Praeparata与Glycyrrhizae Radix et Rhizoma的科学内涵]

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Updated: Jun 4, 2025

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method

Author Spotlight: Optimization of Processing Technology for Tiebangchui with Zanba Based on CRITIC Combined with Box-Behnken Response Surface Method

Published on: May 12, 2023

Yi-Hang Zhao¹, Zhi-Wei Wang¹, Lu-Ping Yang¹

¹School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

|December 19, 2024

概括

这项研究揭示了Glycyrrhizae Radix et Rhizoma (甘草) 如何通过影响类成分转化来影响Aconiti Lateralis Radix Praeparata的加工. 这些发现澄清了中国传统医学的协同处理机制.

科学领域:

传统中国医学 (TCM) 是一种
药理学药理学是指药理学的学科.
化学工程是化学工程的重要组成部分.

背景情况:

传统中医的处理是中国传统医学的一个关键方面.
与辅助剂的协同处理是一种独特而重要的技术.
了解加工过程中的组件转化对于TCM有效性至关重要.

研究的目的:

为了研究Glycyrrhizae Radix et Rhizoma (甘草) 作为辅助剂对Aconiti Lateralis Radix Praeparata的加工的影响.
为了阐明在这种协同处理过程中组件转换的机制.
为TCM的辅助剂加工提供科学见解.

主要方法:

酸性染料颜色测量学酸性染料颜色测量学
超高性能液态染色学-四极飞行时间质谱/质谱 (UPLC-Q-TOF-MS/MS)
密度函数理论 (DFT) 的计算.
分子动力学模拟 (MDS) 模拟

主要成果:

在加工过程中,Glycyrrhizae Radix et Rhizoma显著影响了Aconiti Lateralis Radix Praeparata中类成分的动态转化.
观察到糖酸 (来自甘) 和类 (例如,阿科尼丁,海帕科尼丁) 之间的弱相互作用,影响了它们的转化和含量.
该研究确定了受这种协同处理影响的特定的二聚类化物.

结论:

这项研究阐明了Aconiti Lateralis Radix Praeparata与Glycyrrhizae Radix et Rhizoma处理的内在机制,基于辅助剂-草药相互作用和成分转化.
这项研究为了解TCM中辅助剂加工的原理提供了科学参考.
这些发现有助于现代化和科学验证TCM实践.

关键词:

阿科尼蒂拉特拉利斯拉迪克斯普雷帕拉塔普雷帕拉塔葡萄糖树根 (Glycyrrhizae Radix et Rhizomae) 是一种葡萄糖树根 (Rhizomae) 的一种植物.类化合物是一种类化合物.葡萄糖酸是什么葡萄糖酸是什么互动互动互动互动互动.

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