创新的战略紧急护理的状态患者
1Department of Neurology and Neuroscience Brain Institute University of Virginia, School of Medicine, Health Sciences Center, Box 801330, Charlottesville, VA 22908-1330, USA.
概括
状态 (SE) 是一种神经紧急情况. 鼻腔二类药物可以预防SE,而已建立的SE需要像 levetiracetam,phosphenytoin或valproic acid这样的治疗,尽管需要更好的治疗方法.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 状态 (SE) 是一种神经紧急情况,具有呼吸损害和神经元损伤的风险.
- 在SE中,GABA介导的抑制受到损害,向GABA-A受体的 benzodiazepines 是常见的治疗方法.
- 耐药性患者有SE的风险,需要有效的治疗策略.
研究的目的:
- 审查现有和新兴的治疗状态 (SE).
- 评估二类药物和其他药物的疗效和安全性,用于管理早期和已确定的SE.
- 确定需要改善耐火性SE的处理方法的需求.
主要方法:
- 关于状态的治疗方法的文献综述.
- 在早期SE中分析二胺的疗效,包括给药途径和剂量.
- 在已建立的SE中评估 levetiracetam,phosphenytoin和valproic acid的安全性和有效性.
主要成果:
- 通过鼻子输送的二类药物 (midazolam,diazepam) 在预防SE方面表现有前途.
- 肌肉内注射的米达佐拉姆因实用性和有效性而优先于静脉内注射的洛拉泽,用于早期的SE.
- 列维他,素和酸对已建立的SE同样安全,心血管并发症较低.
- 在已建立的SE中,输入管率为25%,通常是由于呼吸系统的损害;在氏丁治疗的儿童中,输入管率更高.
- 在已建立的SE中, levetiracetam,phosphenytoin和valproic acid的有效性低于50%.
结论:
- 早期使用类药物,特别是肌内用米达佐拉姆进行SE治疗至关重要.
- 虽然 levetiracetam,phosphenytoin和valproic acid是已建立的SE的选择,但它们的有效性是有限的.
- 有一个显著的需要开发更有效的疗法,以建立的状态.
关键词:
这种药物是Benzodiazepines.基胺是一种基胺 (phosphenytoin).胺基氨酸 (ketamine) 是一种可以莱维泰拉塞坦 (Levethiracetam) 是一种状态 的状态 epilepticus.瓦尔酸是一种酸.更多相关视频
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