高血压可能通过甲基马龙酸导致老年人认知功能障碍:来自NHANES 2011-2014年人口的证据
Ying Xu1, Rucheng Chen1, Paulus Torkki2
1School of Public Health, Zhejiang Chinese Medical University, No.548 Binwen Rd, Hangzhou, Zhejiang, China.
BMC geriatrics
|December 20, 2024
概括
甲基马龙酸 (MMA) 在老年人中介于高血压和认知障碍之间的联系. 这种效应在老年男性中更为明显,这表明MMA积累是干预的目标.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 心血管医学 心血管医学
背景情况:
- 高血压是老年人普遍存在的疾病,通常与认知能力下降有关.
- 连接高血压和认知障碍的生物机制需要进一步阐明.
- 甲基马龙酸 (MMA) 被探索为这种关系中的潜在调解者.
研究的目的:
- 研究血清甲基马龙酸 (sMMA) 在60岁及以上成年人高血压和认知功能之间的关联中的调解作用.
- 通过性别和年龄来检查SMMA中介的子组差异.
主要方法:
- 利用了来自2011-2014年国家健康和营养检查调查 (NHANES) 的2762名老年人 (≥60岁) 的数据.
- 使用动物流利性测试 (AFT),数字符号替换测试 (DSST) 和CERAD单词列表学习测试评估认知功能.
- 使用加权多重线性回归和中介分析,根据性别和年龄对子组进行分析.
主要成果:
- 在高血压-认知联系中发现了smma的显著调解作用,解释了11.14%的关系.
- 调解效应在男性 (15.23%) 比女性 (6.61%) 更为显著.
- 在68岁及以上的个体中观察到smma的显著调解,但在年轻的参与者中没有.
结论:
- 通过MMA,高血压可能会导致老年人的认知功能障碍,可能会作为神经毒素.
- 解决MMA积累,可能通过维生素B12补充,可以减轻高血压引起的认知衰退.
- 老年高血压男性 (≥68岁) 需要特别注意与MMA相关的认知衰退.
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