评估学术细节作为克罗地亚初级医疗保健机构的抗生素管理干预措施
Darija Kuruc Poje1, Domagoj Kifer2, Maja Kuharić3
1Department of Pharmacy, General Hospital "dr. Tomislav Bardek", Željka Selingera 1, 4800, Koprivnica, Croatia. darija_kuruc@yahoo.com.
BMC primary care
|December 20, 2024
概括
学术详细说明了克罗地亚急性呼吸道感染的抗生素处方显著减少. 这种有针对性的干预表明,对东南欧的抗菌药物管理有希望.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 抗微生物药物管理委员会
背景情况:
- 急性呼吸道感染 (ARTIs) 在初级保健中经常过度处方抗生素,尽管通常是病毒性.
- 有限的研究存在于学术详细介绍 (AD) 干预在资源有限的设置,如东南欧的抗生素处方的干预.
- 这项研究解决了评估AD对克罗地亚ARTIs和Clostridioides difficile感染 (CDI) 抗生素使用的影响的需要.
研究的目的:
- 评估学术详细化 (AD) 干预对克罗地亚初级保健中急性呼吸道感染 (ARTIs) 抗生素处方实践的影响.
- 评估与抗生素消费相关的Clostridioides difficile感染 (CDI) 发病率的二次结果.
主要方法:
- 在克罗地亚,与对照组进行了一项准实验性可行性研究.
- 从2020年4月1日至30日,医院医疗保健专业人员向初级保健医生 (PCP) 提供了学术详细介绍 (AD) 干预.
- 分析了使用日志线性模型的抗生素处方模式,重点是处方每日定义剂量 (DDD) 每天干预前后.
主要成果:
- 阿尔茨海默病的干预导致急性喉炎 (30%),急性桃体炎 (33%),急性上呼吸道感染 (23%) 和急性支气管炎 (36%) 的抗生素处方显著减少.
- 对急性鼻炎的抗生素处方减少了14%,但没有达到统计学意义.
- 虽然干预县的CDI发病率下降,但县之间的差异在统计学上并不显著.
结论:
- 学术详细说明 (AD) 是一种有效的抗微生物管理策略,用于减少在初级保健中为ARTIs处方抗生素.
- 针对性,由教育工作者领导的干预措施对于促进可持续的处方实践和打击克罗地亚和类似地区的抗菌素耐药性至关重要.
- 需要进一步的研究来优化AD策略及其对抗生素消耗和耐药性的长期影响.
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