血清肌素与囊素C的比率与心力衰竭有关,其中保留了喷射分数
Ruting Wang1, Kai Huang1, Hangfeng Ying1
1Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China.
BMC cardiovascular disorders
|December 20, 2024
概括
较低的sarcopenia指数 (SI) 与心力衰竭与保存的喷射分数 (HFpEF) 有关. 一种使用SI的新型名谱显示了在住院患者中对HFpEF的强大预测能力.
科学领域:
- 心脏病学 心脏病学
- 老年病的医生 老年病的医生
- 生物标志物 生物标志物
背景情况:
- 萨科佩尼亚是心力衰竭 (HF) 中常见的并发症.
- 从血清肌素和细胞素C获得的肉类症指数 (SI) 是评估骨肌肉质量的工具.
- SI与左心室喷射率 (LVEF) 之间的相关性需要进一步调查,特别是在保持喷射率 (HFpEF) 的高频率中.
研究的目的:
- 在心力衰竭 (HF) 患者中分析缩症指数 (SI).
- 专门研究SI在HF患者中具有保留喷射分数 (HFpEF) 的作用.
- 开发和验证使用SI的HFpEF预测模型.
主要方法:
- 建立了一个由229名HF患者和73名健康对照 (HC) 组成的培训队列.
- 包括78名高压患者的外部验证队列.
- 开发了一个HFpEF的预测模型,使用后勤回归和LASSO,通过名录图可视化,并通过内部和外部验证.
主要成果:
- 与HC患者相比,HF患者的SI显著较低 (67.95 ± 13.07与98.57 ± 31.51).
- SI与LVEF显示出明显的负相关性.
- 较低的SI (OR0.948) 与HFpEF独立相关,名谱AUC为0.902,显示出良好的预测性能.
结论:
- 降低的sarcopenia指数 (SI) 是住院患者的HFpEF的独立预测指标.
- 一个包含SI的名图表显示出对HFpEF的显著预测能力.
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