益生菌瘤瘤发生中的微RNA网络:一个范围审查
Sevil Ghaffarzadeh Rad1, Fatemeh Nejadi Orang2, Mahdi Abdoli Shadbad3,4
1Research Center for Evidence-based Medicine, Iranian EBM Centre: A JBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer cell international
|December 20, 2024
概括
微RNAs (miRNAs) 显示出治疗前乳腺瘤的治疗潜力,这是一个常见的垂体瘤. 针对特定的致癌和瘤抑制的miRNAs可以改善治疗结果并减少瘤的进展.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 甲状腺瘤是最常见的垂体腺瘤,导致内分泌失调和不孕症.
- 目前的治疗方法,如多巴胺激动剂和手术,面临着诸如瘤入侵和抵抗等挑战.
- 新的治疗策略是必要的,因为现有的益生菌瘤治疗方法的局限性.
研究的目的:
- 系统地审查和识别涉及益生菌瘤瘤发生的microRNA (miRNA) 网络.
- 为了探索向miRNA表达在prolactinoma中的治疗潜力.
- 为开发基于miRNA的新型治疗方法提供基础.
主要方法:
- 在PubMed,Web of Science,Scopus和Embase数据库中进行了全面的文献搜索.
- 该审查遵循PRISMA-ScR (系统性审查的首选报告项目和范围审查的元分析扩展) 准则.
- 鉴定和分类涉及到益生菌瘤的致癌和抑制瘤的miRNAs.
主要成果:
- 几种miRNA被确定为前性瘤,包括miR-200c,miR-217,miR-93a,miR-93,miR-1299和miR-9.
- 一组不同的miRNA被描述为抑制瘤的,例如miR-137,miR-145-5p,miR-197-3p,miR-29a-3p,miR-489,miR-199a-5p,miR-124,miR-212,miR-129-5p,miR-130a-3p,miR-326,miR-432,miR-548c-3p,miR-570,miR-15,miR-16,miR-26a,miR-196a2和let-7a.
- 失调的miRNA表达在益生菌瘤的发展和进展中起着重要作用.
结论:
- 抑制瘤性miRNA和恢复瘤抑制的miRNA可以减少益生菌分泌和瘤入侵.
- 基于miRNA的治疗方法有望增强多巴胺激素激动剂的疗效,并抑制乳腺瘤的生长.
- 这些发现为未来的翻译研究提供了路线图,用于基于miR的益生菌瘤疗法.
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