脊椎裂变儿童的阳门测量和泌尿动力学:我们可以预测来自膀功能障碍的结肠功能障碍吗?
Ali İhsan Anadolulu1, Ragibe Büşra Erdoğan2, Arzu Canmemiş3
1Department of Pediatric Surgery, Faculty of Medicine, Istanbul Medeniyet University, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Türkiye, Turkey. dr.ali.ihsan.anadolulu@gmail.com.
BMC urology
|December 20, 2024
概括
脊柱裂患者表现出相关的膀和肠道问题. 泌尿动力学和人体测量揭示了膀功能和直肠门抑制反射之间的相关性,有助于管理策略.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 神经胃肠病学 神经胃肠病学
- 发展生物学 发展生物学
背景情况:
- 脊椎裂会影响神经管的发育,导致泌尿和胃肠道症状,这是由于共享的内化和胚胎起源.
- 关于儿科脊柱裂患者的计量力和尿动力学测试之间的关系的研究有限.
- 了解这些联系对于改善患者的健康和福祉至关重要.
研究的目的:
- 调查小儿脊柱裂患者的神经性膀和肠道功能障碍之间的关联.
- 为了划分门测量和泌尿动力学发现之间的关系.
- 识别潜在的相关性,可以为临床管理提供信息.
主要方法:
- 尿动力学和直肠测量对29名患有脊柱裂变的儿科患者进行了尿动力学和直肠测量.
- 如果患者之前曾经进行过直肠外科手术,则被排除在外.
- 分析了膀合规性,空白后残留体积,排毒器活性,直肠压力和直肠合规性的数据.
主要成果:
- 膀功能在下部缺陷 (LD) 和上部缺陷 (UD) 组之间有所不同,LD患者的膀体积较小.
- 在LD (100%) 和UD (72.7%) 两组中都普遍存在detrusor道异能.
- 在膀参数和肠道功能障碍之间发现了正相关性,包括直肠抑制反射 (RAIR) 和最大填充压力.
结论:
- 脊柱裂的神经性肠道和膀功能障碍是复杂的,需要个性化管理.
- 在神经性膀功能障碍患者中,RAIR活性增加可能表明神经性结肠动性.
- 建议使用直肠测量和尿动力学研究进行全面评估,以优化脊柱裂患者的治疗.
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