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更年期状态对女性乳头甲状腺癌患者认知功能的影响:纵向倾向评分与研究结果相匹配
Yuenan Zheng1, Jie Zhao1, Yang Shi1
1Department of Thyroid Surgery, The First Hospital of China Medical University, 155 Nanjing Bei Street, Shenyang, Liaoning Province, 110001, P. R. China.
BMC women's health
|December 20, 2024
概括
患有乳头甲状腺癌 (PTC) 的绝经后妇女面临更高的认知障碍风险,特别是在记忆和整体功能方面. 手术后认知功能逐渐改善,但监测是获得更好的结果的关键.
科学领域:
- 在瘤学瘤学.
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 乳头甲状腺癌 (PTC) 幸存者经常经历认知缺陷.
- 更年期状态是影响这些患者认知功能的潜在因素.
研究的目的:
- 评估更年期状态对女性PTC患者认知功能的影响.
- 识别与认知障碍相关的因素.
- 为了追踪术后的认知变化.
主要方法:
- 使用蒙特利尔认知评估 (MoCA) 对228名女性PTC患者 (40岁以上) 的长度研究.
- 倾向性得分匹配 (PSM) 用于在绝经前和绝经后组之间的基线可比性.
- 统计分析包括曼·惠特尼U测试和后勤回归.
主要成果:
- 与绝经前妇女相比,绝经后妇女在延迟回忆和全球认知方面表现出明显较高的损伤.
- 更年期和农村居住被确定为认知障碍的独立风险因素.
- 认知功能在两个组的6个月研究期间都呈现逐渐改善.
结论:
- 绝经后的状态和农村居住是女性PTC患者认知障碍的重要危险因素.
- 绝经后的女性更容易受到特定的认知缺陷 (延迟回忆,全球认知) 的影响.
- 虽然术后认知功能得到改善,但持续的患者监测和支持对于最佳预后至关重要.
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