在不同剂量方案和基线血清状态之间,E型肝炎疫苗诱导的抗体反应的持续性
Kongxin Zhu1,2, Mengjun Liao1,2, Lu Chen1,2
1State Key Laboratory of Vaccines for Infectious Diseases, Xiang An Biomedicine Laboratory, School of Public Health, Xiamen University, Xiamen, China.
NPJ vaccines
|December 20, 2024
概括
肝炎E疫苗 (HEV239) 显示出至少10年持久的抗体保护. 一剂和两剂都能提供持续的免疫反应,对E型肝炎病毒感染提供显著的保护.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 肝炎E病毒 (HEV) 感染是全球急性病毒性肝炎的重要原因之一.
- 疫苗HEV239已经证明了有效性和安全性,保护时间超过10年.
研究的目的:
- 为了评估HEV239疫苗引起的抗HEVIgG反应的持久性.
- 评估不同基线血清状况的参与者中单剂和两剂疫苗接种方案的长期免疫性.
主要方法:
- 对HEV239疫苗进行第3期试验 (NCT01014845) 的延长.
- 基于疫苗接种剂量和基线血清状况,对参与者的抗HEV IgG抗体水平随时间的推移进行分析.
主要成果:
- 超过50%的最初血清阴性个体在接种两剂疫苗后91个月内保持可检测的抗体.
- 具有先前免疫力的个体在接种单剂疫苗后103个多月内表现出高且持续的抗体水平.
- 单剂和双剂方案都显示出强大的免疫性和抗体持久性.
结论:
- 在HEV239疫苗引起耐久的抗HEVIgG反应,显著的抗体持续观察到103个月.
- 单剂量和双剂量疫苗接种策略都显示出对抗肝炎E病毒的重大和长期保护性益处的潜力.
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