间歇性手脚低温治疗对化疗诱导的外周神经毒性的影响
Li Ran1, Guo Dongxue2, Zhang Zirui2
1Tianjin First Central Hospital, Tianjin, 300190, China.
概括
降低间歇性手脚低温治疗的温度显著降低了化疗诱导的周围神经病变 (CIPN) 症状,并改善了乳腺癌患者的日常活动. 温度在-20至-30°C之间是最有效的,并且耐受性很好.
科学领域:
- 在瘤学瘤学.
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 化疗诱导的周围神经病变 (CIPN) 是乳腺癌患者的普遍和衰弱的副作用.
- CIPN显著损害生活质量和治疗坚持.
- 对CIPN的有效管理策略在支持性癌症护理中至关重要.
研究的目的:
- 评估间歇性手脚低温在不同温度下缓解CIPN症状的有效性.
- 评估低温对患者日常生活活动 (ADL) 能力的影响.
- 在管理CIPN时,确定低温治疗的最佳温度范围.
主要方法:
- 一项随机对照试验,涉及108名接受化疗的乳腺癌患者.
- 三组接受间歇性手脚低温在不同的温度 (0°C至-30°C间隔) 在输液前后15分钟.
- 在整个研究过程中评估了CIPN症状,ADL干扰,耐受性和安全性.
主要成果:
- 最寒冷的温度组 (-20°C至-30°C) 在三次循环后显著减少了麻木,不适,疼痛和虚弱.
- 这组人也表现出更好的平衡和减少刺在六个周期后.
- -20°C至 -30°C的低温干预导致CIPN对ADL总体的影响较低,与最不寒冷的组相比.
结论:
- 间歇性手脚低温,特别是在-20°C至-30°C,是治疗乳腺癌患者中CIPN症状的有效策略.
- 这种疗法显著提高了患者日常活动的功能能力.
- 所有测试的低温温度都被发现是安全的和耐受的,这表明了可行的支持性护理选择.
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