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Updated: Jun 4, 2025

Design, Synthesis, and Photochemical Properties of Clickable Caged Compounds
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在点击释放化学中, орто功能化皮里迪尼尔-四素打破了点击反应率和裂变产量之间的反向相关性

Ron M Versteegen1, Raffaella Rossin2, Ivo A W Filot3

  • 1SyMO-Chem B.V., Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands.

Communications chemistry
|December 20, 2024
PubMed
概括

研究人员改善了抗体-药物合物 (ADC) 的四氨酸触发的有效载荷释放. 新的整形替代四氨酸提高了有效载荷释放效率,使得更低的剂量可用于有效的癌症治疗.

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