听觉脑干反应作为认知的生物标志物.
Yasmeen Hamza1,2, Ye Yang3, Janie Vu3
1Center for Hearing Research, Otolaryngology-Head and Neck Surgery, University of California Irvine, Irvine, CA, USA. y.hamza@soton.ac.uk.
Communications biology
|December 20, 2024
概括
听觉脑干反应 (ABR) 显示出与年龄相关的认知衰退的潜在生物标志物. ABR波V振幅和延迟与认知功能相关,特别是在老年人中,有助于诊断和治疗.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 生物标志物 生物标志物
背景情况:
- 与年龄相关的认知衰退需要可靠的,非侵入性的生物标志物来诊断和管理.
- 以前的研究表明,听觉脑干反应 (ABR) 与老化的认知功能之间存在联系.
研究的目的:
- 为了研究ABR测量和认知功能在广泛的年龄范围内人类队列之间的关联.
- 确定ABR是否可以作为与年龄相关的认知衰退的临床生物标志物.
主要方法:
- 118名人类参与者 (18-92岁) 接受了认知评估和ABR测试.
- 进行了统计分析,包括年龄调整模型和接收器运行特征 (ROC) 分析.
主要成果:
- 认知与年龄相关,听力主要由年龄驱动.
- 在年龄调整后,ABR波V振幅和延迟与认知功能有显著的相关性.
- 在老年人和语言依赖的认知任务中,ABR-认知联系更加明显.
- ROC分析表明,ABR波V振幅在识别良好的认知表现者和表现差者的延迟方面具有很高的准确性.
结论:
- 听觉脑干反应与人类的认知功能有显著的关联,不管年龄如何.
- ABR测量,特别是波V振幅和延迟,具有临床潜力,可以作为诊断和监测与年龄相关的认知衰退的可访问生物标志物.
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