在持续低效率透析中对药物剂量建议的范围审查
Nicholas R Nelson1, Nicholas J Quinn2, Stephanie Bills2
1Department of Translational Science and Inpatient Practice, Wingate University School of Pharmacy, Wingate, North Carolina, USA.
Pharmacotherapy
|December 20, 2024
概括
由于证据有限,持续低效透析 (SLED) 中药物剂量是具有挑战性的. 需要更多的研究来指导药物剂量,并建议对SLED患者进行治疗药物监测.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 临床药房 临床药房
背景情况:
- 持续低效透析 (SLED) 是一种替代性脏替代疗法.
- 在SLED期间最佳药物剂量尚未确立,这构成了临床挑战.
研究的目的:
- 进行范围审查,以识别和总结有关SLED药物剂量的已发表文献.
- 为了回答这个问题:"在持续低效率透析 (SLED) 中描述药物剂量已经发表了什么?"
主要方法:
- 在PubMed,Embase和Scopus数据库中搜索到2022年11月18日.
- 遵循阿克西和奥马利框架和PRISMA-ScR指导方针进行范围审查.
- 包括29项研究,选了230个引用,重点关注成年人药物剂量和SLED.
主要成果:
- 确定了四个药物组:β-乳糖抗生素,非β-乳糖抗生素,抗真菌药物和 levetiracetam.
- 在不同研究中观察到透析速率,透析持续时间和药物剂量的广泛变化.
- 发现异质的结果和评估的药理动力学参数,表明缺乏标准化的方法.
结论:
- 有很少的证据来指导在SLED中适当的药物剂量.
- 在SLED中药物剂量给临床医生带来了重大挑战.
- 需要进行更大规模的研究以建立基于证据的剂量指南,并建议对治疗药物进行监测.
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