Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mutations01:35

Mutations

33.7K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
33.7K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

13.8K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
13.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A pothole-filling strategy for selective targeting of rCUG-repeats associated with myotonic dystrophy type 1.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Spatially Resolved Single-Water Entropy around Amino Acids and Its Link to Hydropathy.

The journal of physical chemistry. B·2026
Same author

Interpreting epidemiological surveillance data: a modelling study based on Pune city.

Scientific reports·2025
Same author

Memory Effects Explain the Fractional Viscosity Dependence of Rates Associated with Internal Friction: Simple Models and Applications to Butane Dihedral Rotation.

The journal of physical chemistry. B·2024
Same author

Nanostructured lipopeptide-based membranomimetics for stabilizing bacteriorhodopsin.

Biomaterials science·2024
Same author

Unraveling the folding-assisted unbinding mechanism of TCF with its binding partner β-catenin.

Physical chemistry chemical physics : PCCP·2024

相关实验视频

Updated: Jun 4, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

1.7K

阿尔法Mut:一个深度强化学习模型,建议螺旋破坏突变.

Prathith Bhargav1, Arnab Mukherjee1,2

  • 1Department of Chemistry, Indian Institute of Science Education and Research Pune, Dr Homi Bhabha Road, Pashan, Pune, Maharashtra 411008, India.

Journal of chemical theory and computation
|December 20, 2024
PubMed
概括

这项研究使用强化学习来预测破坏蛋白质螺旋体的突变,识别结构完整性至关重要的关键氨基酸,并为蛋白质结构分析提供一种新的方法.

科学领域:

  • 蛋白质生物化学和结构生物学
  • 计算生物学和生物信息学
  • 机器学习在科学中的应用.

背景情况:

  • 蛋白质的二次结构,特别是螺旋体,对于生理功能至关重要.
  • 氨基酸成分影响螺旋稳定性,有些残留物促进,有些残留物破坏螺旋形成.
  • 由于环境因素,预测突变对螺旋结构的影响具有挑战性.

研究的目的:

  • 使用强化学习算法开发螺旋破坏突变的预测模型.
  • 为了确定维护蛋白质螺旋结构完整性至关重要的氨基酸.
  • 探索强化学习在预测蛋白质结构变化的新应用.

主要方法:

  • 利用强化学习算法构建了螺旋破坏突变的预测模型.
  • 最初模拟的螺旋破坏独立于蛋白质环境.
  • 扩展模型以预测蛋白质环境中的螺旋对螺旋的影响.
  • 使用免费能源计算验证的预测.

主要成果:

  • 确定只有有限数量的突变会对目标螺旋体造成重大破坏.
  • 成功地扩展了预测模型,以考虑蛋白质环境.
  • 通过严格的自由能量计算验证了模型的准确性.

更多相关视频

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

1.3K

相关实验视频

Last Updated: Jun 4, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
06:50

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

1.7K
Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
10:58

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

17.0K
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
05:56

Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches

Published on: October 13, 2022

1.3K
  • 定点的特定氨基酸对结构完整性至关重要.

    • 结论:

    • 强化学习为预测螺旋破坏突变提供了一种有效的策略.
    • 开发的模型可以识别关键氨基酸,并预测改变蛋白质结构的突变.
    • 这项工作展示了强化学习在蛋白质结构破坏领域的新且强大的用例.