由mRNA电调节T细胞分泌的脑衍生神经营养因子的效率受到其激活状态的高度影响

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Jasper Van den Bos1, Ibo Janssens1, Morgane Vermeulen1

  • 1Laboratory of Experimental Hematology, Vaccine and Infections Disease Institute (VAXINFECTIO), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.

European journal of immunology
|December 20, 2024
PubMed
概括

调节性T细胞 (Tregs) 的基因工程表明,只有激活的Tregs在经过mRNA修饰后分泌来自大脑的神经营养因子 (BDNF). 这一发现对于优化基于Treg的免疫疗法用于自身免疫性疾病和移植至关重要.

关键词:
工程T细胞工程T细胞工程大脑衍生的神经营养因子在mRNA电穿孔过程中,监管T细胞的监管性T细胞

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