医院中的细胞毒性表面污染:当前的做法,挑战和前景
Bertrand Favier1, Claire Simonin1, Sophie Tokatian1
1Pharmacy, Léon Bérard Cancer Center, Lyon, France.
概括
医疗机构中细胞毒药物污染仍然是一个令人担忧的问题. 具有足够样本大小和关键药物跟踪剂的标准化监测对于保护医疗保健专业人员至关重要.
科学领域:
- 职业健康 职业健康 职业健康
- 环境监测 环境监测
- 制药科学 制药科学
背景情况:
- 尽管癌症治疗方面取得了进展,但细胞毒性化疗仍然被广泛使用.
- 处理细胞毒药物的潜在污染对医疗保健专业人员构成风险.
- 需要标准化的环境监测,以确保安全的处理和清洁程序.
研究的目的:
- 审查和标准化监测医疗环境中细胞毒药物污染的方法.
- 为了确定最佳的样本大小和药物跟踪剂,以进行可靠的污染评估.
- 为制定药房和患者护理区域环境监测指南提供信息.
主要方法:
- 在PubMed/Medline和Embase数据库 (2017-2022) 的系统文献搜索.
- 包括报告环境污染结果的研究,用于药房技术人员和护士.
- 分析了29项研究,包括16,196个擦拭样本和189,571个测试.
主要成果:
- 在39.8%的样本和8.2%的测试中检测到总的表面污染.
- 用500-800个样本进行的多中心研究可以减少异质性.
- 建议监测关键的痕迹剂,如环胺和帕克利塔塞尔,最近的值接近0.1 ng/cm2.
结论:
- 医疗保健专业人员面临来自细胞毒性污染的显著暴露风险.
- 标准化监测需要适当的样本大小和高频污染痕迹的量化.
- 为药房和患者护理区域制定污染监测指南至关重要.
相关概念视频
Healthcare Associated Infections II: Preventive Measures
2.4K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.4K
Cleaning, Sterilization, and Disinfection
6.6K
Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease.
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
Cleaning
The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...
6.6K
Standard Precaution
1.9K
Standard precautions are the minimum infection control safeguards used while caring for all patients, irrespective of their disease condition. They help prevent the spread of common infectious microorganisms to healthcare workers, patients, and visitors in all healthcare settings.
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
Hand hygiene is the most crucial means to prevent the transmission of disease. Employers are legally required to provide their workers with personal protective equipment (PPE) to minimize exposure or contact with...
1.9K
Hand hygiene
3.1K
Asepsis is the practice of preventing or breaking the chain of infection. The nurse employs aseptic techniques to prevent the spread of microorganisms and reduce the risk of diseases. Hand hygiene is the cornerstone of aseptic techniques and is classified into medical and surgical asepsis. Medical asepsis includes hand hygiene and the use of gloves. Surgical asepsis, or the sterile technique, refers to practices that render and keep objects and areas free of microorganisms.
Hand washing...
Hand washing...
3.1K
Infection
7.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.7K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
4.0K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.0K


