pH: 在退行性椎间盘中的主要参与者
Matthew A R Trone1, Joshua D Stover1,2, Alejandro Almarza2
1Department of Biomedical Engineering University of Utah Salt Lake City Utah USA.
JOR spine
|December 20, 2024
概括
退行性磁盘疾病的腰部疼痛可能是由酸度引起的. 了解酸度 了解酸度
科学领域:
- 生物医学科学 生物医学科学
- 疼痛研究 疼痛研究
- 脊柱健康 脊柱健康
背景情况:
- 慢性腰部疼痛 (LBP) 是全球领先的残疾,退行性磁盘疾病 (DDD) 是主要原因.
- 目前对DDD对LBP机制的贡献的理解是不完整的,尽管已经确定了ECM分解和炎症等因素.
- 低pH (过酸性) 在DDD疼痛产生中的作用被低估了,需要进一步研究.
研究的目的:
- 在DDD的背景下,审查过酸性对椎间盘 (IVD) 的已知影响.
- 确定关于酸度对DDD相关疼痛的贡献的知识差距.
- 建议未来的研究方向,以了解酸度在DDD疼痛中的作用,并开发有针对性的治疗方法.
主要方法:
- 文献综述综合了当前关于过酸性和DDD的知识.
- 对研究IVD因低pH值而发生的细胞和分子变化的分析.
- 识别研究缺口,并为未来的研究制定建议.
主要成果:
- 过酸性通过促进磁盘细胞和ECM代谢,促进DDD.
- 低pH影响新内尔化,改变机械信号,并影响IVD内的促炎细胞因子和离子通道的表达.
- 现有的DDD疼痛治疗方法的疗效有限.
结论:
- 酸度是DDD和相关的LBP病理生理学的重要,但被低估的因素.
- 进一步的研究至关重要,以阐明DDD中过酸性和 nociception之间的相互作用.
- 更好地了解这些机制对于开发更有效的DDD疼痛治疗方法至关重要.
相关概念视频
pH Regulation in Cells
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pH plays a critical role in maintaining normal cellular activities. It helps maintain the structure and function of various proteins, dictates the charge on cellular membranes, and is crucial for metabolic reactions inside the cell. Moreover, cells use the energy from the proton motive force to generate ATP.
Cytosolic pH
Under physiological conditions, the cytosolic pH is slightly more acidic than the extracellular pH. However, cells must prevent further acidification of their cytosol to...
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Acid-base homeostasis is essential for maintaining normal physiological activities in humans. The pH of various body fluids is strictly regulated because it is critical for the optimal activity of enzymes involved in metabolic reactions. Enzymes are basically proteins, so, any significant change in pH can affect their structure and activity. In humans, pH is regulated using three primary mechanisms— chemical buffer systems, respiratory regulation, and renal regulation.
Respiratory...
Respiratory...
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Stomach pH Regulation
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The human body carefully regulates the internal pH of different organs to maintain homeostasis. For example, while the blood plasma maintains a neutral pH of 7, the stomach lumen has an acidic pH of 1.5 - 3.5. The low pH of stomach lumen helps kill pathogens in the food and break down complex food molecules.
The acid-secreting gastric mucosal epithelial cells (parietal cells) lining the stomach lumen maintain the low pH in the lumen. Numerous ion transporters and channels on these parietal...
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Acid-Base Balance
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The human body maintains a narrow pH range regulated through acid-base balance. This balance is crucial as changes in the hydrogen ion concentration can disrupt cell membrane stability, alter protein structures, and change enzyme activities. The normal pH of arterial blood is 7.4, venous blood and interstitial fluid is 7.35, and intracellular fluid averages 7.0.
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Compensation Mechanisms
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The human body employs intricate mechanisms to counteract changes in blood pH, preventing conditions like acidosis (pH < 7.35) and alkalosis (pH > 7.45). These compensatory responses aim to restore normal arterial blood pH by engaging respiratory or renal systems, depending on the source of the imbalance.
Respiratory Compensation
This mechanism addresses metabolic-induced pH imbalances by adjusting breathing rates. Respiratory compensation begins within minutes of detecting a pH...
Respiratory Compensation
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Respiratory Regulation of Acid-Base Balance
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Respiratory compensation is a vital physiological process that stabilizes blood plasma pH by regulating the partial pressure of carbon dioxide (PCO2), a key determinant of pH levels. Most carbon dioxide in the blood dissolves and converts into carbonic acid (H2CO3). It dissociates into hydrogen ions (H+) and bicarbonate ions (HCO3⁻). There is also an inverse relationship between PCO2 and pH.
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
When carbon dioxide levels increase in the blood, more H+ and HCO3⁻ are...
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