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在乳腺癌患者的新辅助化疗期间,禁食模仿饮食:一种随机对照试验研究

Alireza Bahrami¹, Shirin Haghighi², Mona Malekzadeh Moghani³

¹Department of Clinical Nutrition and Dietetics, School of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Frontiers in nutrition

|December 20, 2024

概括

这项研究发现,禁食模仿饮食 (FMD) 可以减少乳腺癌患者的化疗副作用. 口疫组的吐和中性质减退较少,病理反应率有所改善.

科学领域:

在瘤学瘤学.
营养科学营养科学
临床研究临床研究

背景情况:

临床前研究表明,禁食可以提高化疗的疗效,降低毒性.
接受新辅助化疗的乳腺癌 (BC) 患者经常经历显著的副作用.

研究的目的:

为了评估一种仿制禁食饮食 (FMD) 对接受新辅助化疗的HER2-阴性BC患者的毒性和疗效的影响.
在化疗期间评估与口炎相关的代谢和炎症变化.

主要方法:

44名HER2-阴性BC患者被随机分配给接受口病或常规饮食3天前和8次化疗周期期间.
效率,毒性,血液学,代谢和炎症标志物被监测和组之间的比较.

主要成果:

与对照组相比,口疫组的III级吐和中性质减退率明显较低.
患有口腔炎的患者的红细胞和中性粒细胞数量较高,并经历了胰岛素样生长因子-1 (IGF-1) 和hs-CRP水平的降低.
在口炎组中观察到病理和放射性反应率的改善,这表明治疗效率有所提高.

结论:

禁食模仿饮食在接受化疗的乳腺癌患者中耐受良好.
口病可以减轻化疗引起的毒性,并积极影响代谢和炎症标志物.
在乳腺癌患者中,口病可能会增强整体治疗反应.

关键词:

乳腺癌乳腺癌乳腺癌化疗化疗是一种化学疗法.禁食禁食是一種禁食.禁食模仿饮食禁食模仿饮食毒性的毒性毒性的毒性

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